Abstract
Myocardial infarction (MI) is a leading cause of death and disabilities. Inflammatory cells play a vital role in the process of postinfarction remodeling and repair. Inflammatory cell infiltration into the infarct site can be monitored using T 2*-weighted MRI following an intravenous administration of iron oxide particles. In this study, various doses of micrometer-sized iron oxide particles (1.1-14.5 μg Fe/g body weight) were injected into the mouse blood stream before a surgical induction of MI. Cardiac MRIs were performed at 3, 7, 14, and 21 days postinfarction to monitor the signal attenuation at the infarct site. A dose-dependent phenomenon of signal attenuation was observed at the infarct site, with a higher dose leading to a darker signal. The study suggests an optimal temporal window for monitoring iron oxide particles-labeled inflammatory cell infiltration to the infarct site using MRI. The dose-dependent signal attenuation also indicates an optimal iron oxide dose of approximately 9.1-14.5 μg Fe/g body weight. A lower dose cannot differentiate the signal attenuation, whereas a higher dose would cause significant artifacts. This iron oxide-enhanced MRI technique can potentially be used to monitor cell migration and infiltration at the pathological site or to confirm any cellular response following some specific treatment strategies.
Original language | English (US) |
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Pages (from-to) | 1353-1361 |
Number of pages | 9 |
Journal | Magnetic resonance in medicine |
Volume | 66 |
Issue number | 5 |
DOIs | |
State | Published - Nov 2011 |
Externally published | Yes |
Keywords
- MRI
- dose-dependent
- inflammatory cell imaging
- micrometer-sized iron oxide particles
- myocardial infarction
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging