Assessment of lung-cancer mortality reduction from CT Screening

Claudia I. Henschke; Paolo Boffetta; Olga Gorlova; Rowena Yip; John O. DeLancey; Millennia Foy

doi:10.1016/j.lungcan.2010.10.025

Assessment of lung-cancer mortality reduction from CT Screening

Claudia I. Henschke, Paolo Boffetta, Olga Gorlova, Rowena Yip, John O. DeLancey, Millennia Foy

Epidemiology

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Background: CT screening has been shown to increase lung cancer curability and we now assess the corresponding reduction in lung cancer mortality. Methods: Lung-cancer mortality in a cohort of 7995 smokers who underwent CT screening for lung cancer in New York State (NYS) was compared with two unscreened cohorts (CPS-II and CARET). The standardized mortality ratio (SMR) of observed to expected lung cancer deaths for NYS was jointly adjusted for age, sex, and smoking history. As more current NYS smokers might have quit as a result of the screening, thus reducing deaths from lung cancer, another analysis was restricted to those participants smoking at entry and still smoking 6 years later. Results: The SMR was 64/99.8=0.64 (P=0.84×10^-4) and 28/77.6=0.36 (P=0.83×10^-10), showing a significant reduction in deaths from lung cancer of 36% and 64% for CPS-II and CARET, respectively. Considering participants who were smoking at entry and still smoking 6 years later, the SMR using CPS-II rates was 29/49.1=0.59 (P=0.001) and using CARET rates it was 21/57.4=0.37 (P=0.31×10^-7). Conclusions: CT screening significantly reduces lung-cancer mortality.

Original language	English (US)
Pages (from-to)	328-332
Number of pages	5
Journal	Lung Cancer
Volume	71
Issue number	3
DOIs	https://doi.org/10.1016/j.lungcan.2010.10.025
State	Published - Mar 2011

Keywords

CARET
CPS-II
CT screening
Lung cancer
Mortality reduction

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine
Cancer Research

Access to Document

10.1016/j.lungcan.2010.10.025

Cite this

@article{9d2b72c7cf7e49ca868942d2163d36ac,

title = "Assessment of lung-cancer mortality reduction from CT Screening",

abstract = "Background: CT screening has been shown to increase lung cancer curability and we now assess the corresponding reduction in lung cancer mortality. Methods: Lung-cancer mortality in a cohort of 7995 smokers who underwent CT screening for lung cancer in New York State (NYS) was compared with two unscreened cohorts (CPS-II and CARET). The standardized mortality ratio (SMR) of observed to expected lung cancer deaths for NYS was jointly adjusted for age, sex, and smoking history. As more current NYS smokers might have quit as a result of the screening, thus reducing deaths from lung cancer, another analysis was restricted to those participants smoking at entry and still smoking 6 years later. Results: The SMR was 64/99.8=0.64 (P=0.84×10-4) and 28/77.6=0.36 (P=0.83×10-10), showing a significant reduction in deaths from lung cancer of 36% and 64% for CPS-II and CARET, respectively. Considering participants who were smoking at entry and still smoking 6 years later, the SMR using CPS-II rates was 29/49.1=0.59 (P=0.001) and using CARET rates it was 21/57.4=0.37 (P=0.31×10-7). Conclusions: CT screening significantly reduces lung-cancer mortality.",

keywords = "CARET, CPS-II, CT screening, Lung cancer, Mortality reduction",

author = "Henschke, {Claudia I.} and Paolo Boffetta and Olga Gorlova and Rowena Yip and DeLancey, {John O.} and Millennia Foy",

note = "Funding Information: Sources of funding: Screenings were supported by grants from the National Institutes of Health R01-CA-63393 , R01-CA-78905 , The City of New York, Department of Health and Mental Hygiene, New York State Office of Science, Technology and Academic Research (NYSTAR), General Electric, Kodak, Empire Blue Cross and Blue Shield, The Starr Foundation, Ernest E. Stempel Foundation, The New York Community Trust, The Rogers Family Fund, and AMDeC Foundation, Inc.",

year = "2011",

month = mar,

doi = "10.1016/j.lungcan.2010.10.025",

language = "English (US)",

volume = "71",

pages = "328--332",

journal = "Lung Cancer",

issn = "0169-5002",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - Assessment of lung-cancer mortality reduction from CT Screening

AU - Henschke, Claudia I.

AU - Boffetta, Paolo

AU - Gorlova, Olga

AU - Yip, Rowena

AU - DeLancey, John O.

AU - Foy, Millennia

N1 - Funding Information: Sources of funding: Screenings were supported by grants from the National Institutes of Health R01-CA-63393 , R01-CA-78905 , The City of New York, Department of Health and Mental Hygiene, New York State Office of Science, Technology and Academic Research (NYSTAR), General Electric, Kodak, Empire Blue Cross and Blue Shield, The Starr Foundation, Ernest E. Stempel Foundation, The New York Community Trust, The Rogers Family Fund, and AMDeC Foundation, Inc.

PY - 2011/3

Y1 - 2011/3

N2 - Background: CT screening has been shown to increase lung cancer curability and we now assess the corresponding reduction in lung cancer mortality. Methods: Lung-cancer mortality in a cohort of 7995 smokers who underwent CT screening for lung cancer in New York State (NYS) was compared with two unscreened cohorts (CPS-II and CARET). The standardized mortality ratio (SMR) of observed to expected lung cancer deaths for NYS was jointly adjusted for age, sex, and smoking history. As more current NYS smokers might have quit as a result of the screening, thus reducing deaths from lung cancer, another analysis was restricted to those participants smoking at entry and still smoking 6 years later. Results: The SMR was 64/99.8=0.64 (P=0.84×10-4) and 28/77.6=0.36 (P=0.83×10-10), showing a significant reduction in deaths from lung cancer of 36% and 64% for CPS-II and CARET, respectively. Considering participants who were smoking at entry and still smoking 6 years later, the SMR using CPS-II rates was 29/49.1=0.59 (P=0.001) and using CARET rates it was 21/57.4=0.37 (P=0.31×10-7). Conclusions: CT screening significantly reduces lung-cancer mortality.

AB - Background: CT screening has been shown to increase lung cancer curability and we now assess the corresponding reduction in lung cancer mortality. Methods: Lung-cancer mortality in a cohort of 7995 smokers who underwent CT screening for lung cancer in New York State (NYS) was compared with two unscreened cohorts (CPS-II and CARET). The standardized mortality ratio (SMR) of observed to expected lung cancer deaths for NYS was jointly adjusted for age, sex, and smoking history. As more current NYS smokers might have quit as a result of the screening, thus reducing deaths from lung cancer, another analysis was restricted to those participants smoking at entry and still smoking 6 years later. Results: The SMR was 64/99.8=0.64 (P=0.84×10-4) and 28/77.6=0.36 (P=0.83×10-10), showing a significant reduction in deaths from lung cancer of 36% and 64% for CPS-II and CARET, respectively. Considering participants who were smoking at entry and still smoking 6 years later, the SMR using CPS-II rates was 29/49.1=0.59 (P=0.001) and using CARET rates it was 21/57.4=0.37 (P=0.31×10-7). Conclusions: CT screening significantly reduces lung-cancer mortality.

KW - CARET

KW - CPS-II

KW - CT screening

KW - Lung cancer

KW - Mortality reduction

UR - http://www.scopus.com/inward/record.url?scp=79851512500&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79851512500&partnerID=8YFLogxK

U2 - 10.1016/j.lungcan.2010.10.025

DO - 10.1016/j.lungcan.2010.10.025

M3 - Article

C2 - 21168236

AN - SCOPUS:79851512500

SN - 0169-5002

VL - 71

SP - 328

EP - 332

JO - Lung Cancer

JF - Lung Cancer

IS - 3

ER -

Assessment of lung-cancer mortality reduction from CT Screening

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this