Assignment of retinoblastoma susceptibility gene to mouse chromosome 14

Chih Lin Hsieh; Wen Hwa Lee; Eva Y.H.P. Lee; Ann M. Killary; Peter A. Lalley; Susan L. Naylor

doi:10.1007/BF01534896

Assignment of retinoblastoma susceptibility gene to mouse chromosome 14

Chih Lin Hsieh, Wen Hwa Lee, Eva Y.H.P. Lee, Ann M. Killary, Peter A. Lalley, Susan L. Naylor

Research output: Contribution to journal › Article › peer-review

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Abstract

A human cDNA probe was used to screen a panel of mouse-Chinese hamster somatic cell hybrids to determine the chromosomal location of the retinoblastoma susceptibility gene (Rb-1)in mouse. The Rb-1 gene mapped to mouse chromosome 14. Thus, the retinoblastoma susceptibility gene is syntenic with esterase 10 (the mouse homolog of human esterase D). The chromosomal assignment of the mouse Rb-1 gene was further confirmed by using the same probe to study mouse-rat microcell hybrids. Since the human retinoblastoma susceptibility gene (RB1)along with the gene for esterase D is on chromosome 13q14, these data indicate this linkage group is conserved in man and mouse.

Original language	English (US)
Pages (from-to)	461-464
Number of pages	4
Journal	Somatic Cell and Molecular Genetics
Volume	15
Issue number	5
DOIs	https://doi.org/10.1007/BF01534896
State	Published - Sep 1989
Externally published	Yes

ASJC Scopus subject areas

Genetics
Cell Biology

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title = "Assignment of retinoblastoma susceptibility gene to mouse chromosome 14",

abstract = "A human cDNA probe was used to screen a panel of mouse-Chinese hamster somatic cell hybrids to determine the chromosomal location of the retinoblastoma susceptibility gene (Rb-1)in mouse. The Rb-1 gene mapped to mouse chromosome 14. Thus, the retinoblastoma susceptibility gene is syntenic with esterase 10 (the mouse homolog of human esterase D). The chromosomal assignment of the mouse Rb-1 gene was further confirmed by using the same probe to study mouse-rat microcell hybrids. Since the human retinoblastoma susceptibility gene (RB1)along with the gene for esterase D is on chromosome 13q14, these data indicate this linkage group is conserved in man and mouse.",

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AU - Hsieh, Chih Lin

AU - Lee, Wen Hwa

AU - Lee, Eva Y.H.P.

AU - Killary, Ann M.

AU - Lalley, Peter A.

AU - Naylor, Susan L.

PY - 1989/9

Y1 - 1989/9

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AB - A human cDNA probe was used to screen a panel of mouse-Chinese hamster somatic cell hybrids to determine the chromosomal location of the retinoblastoma susceptibility gene (Rb-1)in mouse. The Rb-1 gene mapped to mouse chromosome 14. Thus, the retinoblastoma susceptibility gene is syntenic with esterase 10 (the mouse homolog of human esterase D). The chromosomal assignment of the mouse Rb-1 gene was further confirmed by using the same probe to study mouse-rat microcell hybrids. Since the human retinoblastoma susceptibility gene (RB1)along with the gene for esterase D is on chromosome 13q14, these data indicate this linkage group is conserved in man and mouse.

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Assignment of retinoblastoma susceptibility gene to mouse chromosome 14

Abstract

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