Association between δ-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: A meta-regression analysis

Yang Zhao; Lu Wang; Hong Bing Shen; Zhong Xu Wang; Qing Yi Wei; Feng Chen

doi:10.1080/15287390701550946

Association between δ-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: A meta-regression analysis

Yang Zhao, Lu Wang, Hong Bing Shen, Zhong Xu Wang, Qing Yi Wei, Feng Chen

Epidemiology

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

A meta-regression analysis was undertaken to evaluate the association between δ-aminolevulinic acid dehydratase (ALAD) genotypes and blood lead levels obtained from data published in various journals. In total, 15 studies were included in the final analysis. Both fixed effects and random effects models were used to undertake the pooled analysis. Using a fixed effects model, pooled estimates of mean differences of various ALAD genotypes was significant at 0.61μg/dl. Using a random effects model, the pooled estimate was also significant at 1.51μg/dl. Data indicated that certain ALAD genotypes may affect the susceptibility of humans to lead.

Original language	English (US)
Pages (from-to)	1986-1994
Number of pages	9
Journal	Journal of Toxicology and Environmental Health - Part A: Current Issues
Volume	70
Issue number	23
DOIs	https://doi.org/10.1080/15287390701550946
State	Published - Jan 2007

ASJC Scopus subject areas

Toxicology
Health, Toxicology and Mutagenesis

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title = "Association between δ-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: A meta-regression analysis",

abstract = "A meta-regression analysis was undertaken to evaluate the association between δ-aminolevulinic acid dehydratase (ALAD) genotypes and blood lead levels obtained from data published in various journals. In total, 15 studies were included in the final analysis. Both fixed effects and random effects models were used to undertake the pooled analysis. Using a fixed effects model, pooled estimates of mean differences of various ALAD genotypes was significant at 0.61μg/dl. Using a random effects model, the pooled estimate was also significant at 1.51μg/dl. Data indicated that certain ALAD genotypes may affect the susceptibility of humans to lead.",

author = "Yang Zhao and Lu Wang and Shen, {Hong Bing} and Wang, {Zhong Xu} and Wei, {Qing Yi} and Feng Chen",

note = "Funding Information: This study was supported by the National Key Basic Research Program grant (202CB512910), National Natural Science Foundation grant (30571619), and Natural Science Foundation of Jiangsu Province grant (04KJB310081).",

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AU - Wei, Qing Yi

AU - Chen, Feng

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Association between δ-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: A meta-regression analysis

Abstract

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