TY - JOUR
T1 - Association Between Age at Diagnosis of Type 2 Diabetes and Cardiovascular Diseases
T2 - A Nationwide, Population-Based, Cohort Study
AU - the REACTION Study Group
AU - Hu, Chunyan
AU - Lin, Lin
AU - Zhu, Yujing
AU - Zhang, Yi
AU - Wang, Shuangyuan
AU - Zhang, Jie
AU - Qi, Hongyan
AU - Li, Mian
AU - Zhu, Yuanyue
AU - Huo, Yanan
AU - Wan, Qin
AU - Qin, Yingfen
AU - Hu, Ruying
AU - Shi, Lixin
AU - Su, Qing
AU - Yu, Xuefeng
AU - Yan, Li
AU - Qin, Guijun
AU - Tang, Xulei
AU - Chen, Gang
AU - Xu, Min
AU - Xu, Yu
AU - Wang, Tiange
AU - Zhao, Zhiyun
AU - Gao, Zhengnan
AU - Wang, Guixia
AU - Shen, Feixia
AU - Luo, Zuojie
AU - Chen, Li
AU - Li, Qiang
AU - Ye, Zhen
AU - Zhang, Yinfei
AU - Liu, Chao
AU - Wang, Youmin
AU - Yang, Tao
AU - Deng, Huacong
AU - Chen, Lulu
AU - Zeng, Tianshu
AU - Li, Donghui
AU - Zhao, Jiajun
AU - Mu, Yiming
AU - Bi, Yufang
AU - Wang, Weiqing
AU - Ning, Guang
AU - Wu, Shengli
AU - Chen, Yuhong
AU - Lu, Jieli
N1 - Publisher Copyright:
© Copyright © 2021 Hu, Lin, Zhu, Zhang, Wang, Zhang, Qi, Li, Zhu, Huo, Wan, Qin, Hu, Shi, Su, Yu, Yan, Qin, Tang, Chen, Xu, Xu, Wang, Zhao, Gao, Wang, Shen, Luo, Chen, Li, Ye, Zhang, Liu, Wang, Yang, Deng, Chen, Zeng, Li, Zhao, Mu, Bi, Wang, Ning, Wu, Chen and Lu.
PY - 2021/10/4
Y1 - 2021/10/4
N2 - Objectives: Nationwide studies focusing on the impact of early-onset type 2 diabetes and obesity on the development of cardiovascular diseases (CVD) are limited in China. We aimed to investigate the association between age at diagnosis of type 2 diabetes and the risk of CVD, and to further examine the modifying effect of obesity on this association among Chinese adults. Methods: This study included 23,961 participants with previously diagnosed diabetes from a large nationwide population-based cohort study across mainland China. With an interviewer-assisted questionnaire, we collected detailed information on CVDs. Logistic regression analysis was used to evaluate the risk of CVDs associated with age at diagnosis of diabetes. Results: Compared with patients with late-onset diabetes (≥60 years), those with earlier-onset diabetes had increased risks for CVD, with adjusted ORs (95% CIs) of 1.72 (1.36-2.17), 1.52 (1.31-1.75) and 1.33 (1.19-1.48) for patients diagnosed aged <40, 40-49 and 50-59 years, respectively. Each 5-year earlier age at diagnosis of type 2 diabetes was significantly associated with 14% increased risk of CVD (OR, 1.14; 95%CI, 1.11-1.18). This association was more prominent for patients with obesity than those with normal body mass index (BMI). Significant interaction was detected between age at diagnosis and BMI categories on CVD risk (P for interaction=0.0457). Conclusion: Early-onset type 2 diabetes was significantly associated with higher risk of CVD, and this association was more prominent among patients with obesity.
AB - Objectives: Nationwide studies focusing on the impact of early-onset type 2 diabetes and obesity on the development of cardiovascular diseases (CVD) are limited in China. We aimed to investigate the association between age at diagnosis of type 2 diabetes and the risk of CVD, and to further examine the modifying effect of obesity on this association among Chinese adults. Methods: This study included 23,961 participants with previously diagnosed diabetes from a large nationwide population-based cohort study across mainland China. With an interviewer-assisted questionnaire, we collected detailed information on CVDs. Logistic regression analysis was used to evaluate the risk of CVDs associated with age at diagnosis of diabetes. Results: Compared with patients with late-onset diabetes (≥60 years), those with earlier-onset diabetes had increased risks for CVD, with adjusted ORs (95% CIs) of 1.72 (1.36-2.17), 1.52 (1.31-1.75) and 1.33 (1.19-1.48) for patients diagnosed aged <40, 40-49 and 50-59 years, respectively. Each 5-year earlier age at diagnosis of type 2 diabetes was significantly associated with 14% increased risk of CVD (OR, 1.14; 95%CI, 1.11-1.18). This association was more prominent for patients with obesity than those with normal body mass index (BMI). Significant interaction was detected between age at diagnosis and BMI categories on CVD risk (P for interaction=0.0457). Conclusion: Early-onset type 2 diabetes was significantly associated with higher risk of CVD, and this association was more prominent among patients with obesity.
KW - age at diagnosis of diabetes
KW - cardiovascular disease
KW - early-onset diabetes
KW - obesity
KW - type 2 diabetes
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UR - http://www.scopus.com/inward/citedby.url?scp=85117305364&partnerID=8YFLogxK
U2 - 10.3389/fendo.2021.717069
DO - 10.3389/fendo.2021.717069
M3 - Article
C2 - 34671316
AN - SCOPUS:85117305364
SN - 1664-2392
VL - 12
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
M1 - 717069
ER -