TY - JOUR
T1 - Association Between PARP-1 V762A Polymorphism and Cancer
T2 - Susceptibility: A meta-analysis
AU - Yu, Hongping
AU - Ma, Hongxia
AU - Yin, Ming
AU - Wei, Qingyi
PY - 2012/1
Y1 - 2012/1
N2 - Poly(ADP-ribose) polymerase-1 (PARP-1 catalyzes poly(ADP-ribosyl)ation to various proteins involved in many cellular processes, including DNA damage detection and repair and cell proliferation and death. PARP-1 has been implicated in human carcinogenesis, but the association between the most-studied PARP-1 V762A polymorphism (rs1136410) and risk of various cancers was reported with inconclusive results. The aim of this study was to assess the association between the PARP-1 V762A polymorphism and cancer risk. A meta-analysis of 21 studies with 12,027 cancer patients and 14,106 cancerfree controls was conducted to evaluate the strength of the association using odds ratio (OR) with 95% confidence interval (CI). Overall, no significant association was found between the PARP-1 V762A polymorphism and cancer risk. In the stratified analyses, however, it was found that the variant A allele of the PARP-1 V762A polymorphism was associated with an increased risk of cancer among Asian populations (VA1AA vs. VV: OR51.11, 95% CI: 1.01-1.23; Pheterogeneity50.210), but a decreased risk of cancer (VA1AA vs. VV: OR50.89, 95% CI: 0.80-1.00; Pheterogeneity50.004) among Caucasian populations, especially for glioma risk (OR50.79, 95% CI: 0.69-0.90; Pheterogeneity50.800). This meta-analysis found evidence for an association of the PARP-1 V 762A polymorphism with increased risk of cancer among Asians, but decreased risk of cancer among Caucasians, particularly of glioma. Further well-designed studies with large sample sizes of different ethnic populations and different cancer types are warranted to confirm these findings.
AB - Poly(ADP-ribose) polymerase-1 (PARP-1 catalyzes poly(ADP-ribosyl)ation to various proteins involved in many cellular processes, including DNA damage detection and repair and cell proliferation and death. PARP-1 has been implicated in human carcinogenesis, but the association between the most-studied PARP-1 V762A polymorphism (rs1136410) and risk of various cancers was reported with inconclusive results. The aim of this study was to assess the association between the PARP-1 V762A polymorphism and cancer risk. A meta-analysis of 21 studies with 12,027 cancer patients and 14,106 cancerfree controls was conducted to evaluate the strength of the association using odds ratio (OR) with 95% confidence interval (CI). Overall, no significant association was found between the PARP-1 V762A polymorphism and cancer risk. In the stratified analyses, however, it was found that the variant A allele of the PARP-1 V762A polymorphism was associated with an increased risk of cancer among Asian populations (VA1AA vs. VV: OR51.11, 95% CI: 1.01-1.23; Pheterogeneity50.210), but a decreased risk of cancer (VA1AA vs. VV: OR50.89, 95% CI: 0.80-1.00; Pheterogeneity50.004) among Caucasian populations, especially for glioma risk (OR50.79, 95% CI: 0.69-0.90; Pheterogeneity50.800). This meta-analysis found evidence for an association of the PARP-1 V 762A polymorphism with increased risk of cancer among Asians, but decreased risk of cancer among Caucasians, particularly of glioma. Further well-designed studies with large sample sizes of different ethnic populations and different cancer types are warranted to confirm these findings.
KW - Case-control study
KW - DNA repair
KW - Meta-analysis
KW - Polymorphism
KW - Susceptibility
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U2 - 10.1002/gepi.20663
DO - 10.1002/gepi.20663
M3 - Article
C2 - 22127734
AN - SCOPUS:84859106641
SN - 0741-0395
VL - 36
SP - 56
EP - 65
JO - Genetic epidemiology
JF - Genetic epidemiology
IS - 1
ER -