TY - JOUR
T1 - Association between polymorphisms in the GSTA4 gene and risk of lung cancer
T2 - A case-control study in a southeastern chinese population
AU - Qian, Ji
AU - Jing, Jianying
AU - Jin, Guangfu
AU - Wang, Haifeng
AU - Wang, Yi
AU - Liu, Hongliang
AU - Wang, Haijian
AU - Li, Rui
AU - Fan, Weiwei
AU - An, Yu
AU - Sun, Weiwei
AU - Wang, Yi
AU - Ma, Hongxia
AU - Miao, Ruifeng
AU - Hu, Zhibin
AU - Jin, Li
AU - Wei, Qingyi
AU - Shen, Hongbing
AU - Huang, Wei
AU - Lu, Daru
PY - 2009/3
Y1 - 2009/3
N2 - GST Alpha 4 (GSTA4) has an important role in the protection against oxidative stress induced by carcinogens such as tobacco smoke. However, few studies investigated the association between GSTA4 polymorphisms and lung cancer risk. We genotyped three selected GSTA4 SNPs (rs182623 - 1718:T > A, rs3798804 + 5034:G > A and rs316141 + 13984:C > T) in a case-control study of 500 lung cancer patients and 517 cancer-free controls and evaluated the association between these SNPs and risk of lung cancer in this Han Chinese population. We found that there was a significant difference in genotype and allele frequency distributions of GSTA4 -1718 between the cases and the controls (P=0.006 and P=0.003, respectively). Compared with the GSTA4 -1718TT genotype, individuals with the TA + AA genotypes had a significantly decreased risk of lung cancer (adjusted OR, 0.63; 95% CI, 0.47-0.84; P=0.006). Although there were no such statistical differences between the cases and controls at the loci +5034 and +13984, nor for histological types, individuals carrying the genotypes of -1718TA, +5034GG and +13984CT had a significantly decreased lung cancer risk (OR, 0.37; 95% CI, 0.23-0.61; P < 0.0001), especially for those smokers who smoked ≤25 pack-years (P < 0.000001). These results need to be confirmed in larger studies with different ethnic groups.
AB - GST Alpha 4 (GSTA4) has an important role in the protection against oxidative stress induced by carcinogens such as tobacco smoke. However, few studies investigated the association between GSTA4 polymorphisms and lung cancer risk. We genotyped three selected GSTA4 SNPs (rs182623 - 1718:T > A, rs3798804 + 5034:G > A and rs316141 + 13984:C > T) in a case-control study of 500 lung cancer patients and 517 cancer-free controls and evaluated the association between these SNPs and risk of lung cancer in this Han Chinese population. We found that there was a significant difference in genotype and allele frequency distributions of GSTA4 -1718 between the cases and the controls (P=0.006 and P=0.003, respectively). Compared with the GSTA4 -1718TT genotype, individuals with the TA + AA genotypes had a significantly decreased risk of lung cancer (adjusted OR, 0.63; 95% CI, 0.47-0.84; P=0.006). Although there were no such statistical differences between the cases and controls at the loci +5034 and +13984, nor for histological types, individuals carrying the genotypes of -1718TA, +5034GG and +13984CT had a significantly decreased lung cancer risk (OR, 0.37; 95% CI, 0.23-0.61; P < 0.0001), especially for those smokers who smoked ≤25 pack-years (P < 0.000001). These results need to be confirmed in larger studies with different ethnic groups.
KW - Genetic polymorphism
KW - Genetic susceptibility
KW - Glutathione S transferase A4 (GSTA4)
KW - Lung cancer
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U2 - 10.1002/mc.20478
DO - 10.1002/mc.20478
M3 - Article
C2 - 18767114
AN - SCOPUS:62349141446
SN - 0899-1987
VL - 48
SP - 253
EP - 259
JO - Molecular Carcinogenesis
JF - Molecular Carcinogenesis
IS - 3
ER -