TY - JOUR
T1 - Association of plasma volume status with outcomes in hospitalized Covid-19 ARDS patients
T2 - A retrospective multicenter observational study
AU - Balasubramanian, Prasanth
AU - Isha, Shahin
AU - Hanson, Abby J.
AU - Jenkins, Anna
AU - Satashia, Parthkumar
AU - Balavenkataraman, Arvind
AU - Huespe, Iván A.
AU - Bansal, Vikas
AU - Caples, Sean M.
AU - Khan, Syed Anjum
AU - Jain, Nitesh K.
AU - Kashyap, Rahul
AU - Cartin-Ceba, Rodrigo
AU - Nates, Joseph L.
AU - Reddy, Dereddi R.S.
AU - Milian, Ricardo Diaz
AU - Farres, Houssam
AU - Martin, Archer K.
AU - Patel, Parag C.
AU - Smith, Michael A.
AU - Shapiro, Anna B.
AU - Bhattacharyya, Anirban
AU - Chaudhary, Sanjay
AU - Kiley, Sean P.
AU - Quinones, Quintin J.
AU - Patel, Neal M.
AU - Guru, Pramod K.
AU - Moreno Franco, Pablo
AU - Sanghavi, Devang K.
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/12
Y1 - 2023/12
N2 - Purpose: To evaluate the association of estimated plasma volume (ePV) and plasma volume status (PVS) on admission with the outcomes in COVID-19-related acute respiratory distress syndrome (ARDS) patients. Materials and methods: We performed a retrospective multi-center study on COVID-19-related ARDS patients who were admitted to the Mayo Clinic Enterprise health system. Plasma volume was calculated using the formulae for ePV and PVS, and these variables were analyzed for correlation with patient outcomes. Results: Our analysis included 1298 patients with sequential organ failure assessment (SOFA) respiratory score ≥ 2 (PaO2/FIO2 ≤300 mmHg) and a mortality rate of 25.96%. A Cox proportional multivariate analysis showed PVS but not ePV as an independent correlation with 90-day mortality after adjusting for the covariates (HR: 1.015, 95% CI: 1.005–1.025, p = 0.002 and HR 1.054, 95% CI 0.958–1.159, p = 0.278 respectively). Conclusion: A lower PVS on admission correlated with a greater chance of survival in COVID-19-related ARDS patients. The role of PVS in guiding fluid management should be investigated in future prospective studies.
AB - Purpose: To evaluate the association of estimated plasma volume (ePV) and plasma volume status (PVS) on admission with the outcomes in COVID-19-related acute respiratory distress syndrome (ARDS) patients. Materials and methods: We performed a retrospective multi-center study on COVID-19-related ARDS patients who were admitted to the Mayo Clinic Enterprise health system. Plasma volume was calculated using the formulae for ePV and PVS, and these variables were analyzed for correlation with patient outcomes. Results: Our analysis included 1298 patients with sequential organ failure assessment (SOFA) respiratory score ≥ 2 (PaO2/FIO2 ≤300 mmHg) and a mortality rate of 25.96%. A Cox proportional multivariate analysis showed PVS but not ePV as an independent correlation with 90-day mortality after adjusting for the covariates (HR: 1.015, 95% CI: 1.005–1.025, p = 0.002 and HR 1.054, 95% CI 0.958–1.159, p = 0.278 respectively). Conclusion: A lower PVS on admission correlated with a greater chance of survival in COVID-19-related ARDS patients. The role of PVS in guiding fluid management should be investigated in future prospective studies.
KW - ARDS
KW - COVID-19
KW - Estimated plasma volume
KW - Fluid therapy
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U2 - 10.1016/j.jcrc.2023.154378
DO - 10.1016/j.jcrc.2023.154378
M3 - Article
C2 - 37479551
AN - SCOPUS:85165474498
SN - 0883-9441
VL - 78
JO - Journal of critical care
JF - Journal of critical care
M1 - 154378
ER -