TY - JOUR
T1 - Association of polymorphisms in one-carbon metabolizing genes and lung cancer risk
T2 - a case-control study in Chinese population
AU - Liu, Hongliang
AU - Jin, Guangfu
AU - Wang, Haifeng
AU - Wu, Wenting
AU - Liu, Yanhong
AU - Qian, Ji
AU - Fan, Weiwei
AU - Ma, Hongxia
AU - Miao, Ruifen
AU - Hu, Zhibin
AU - Sun, Weiwei
AU - Wang, Yi
AU - Jin, Li
AU - Wei, Qingyi
AU - Shen, Hongbing
AU - Huang, Wei
AU - Lu, Daru
N1 - Funding Information:
This work was supported in part by the China National Key Basic Research Program Grants 2002CB512902 (to D. Lu & H. Shen), 2002BA711A10 and 2004CB518605 (to W. Huang), National Outstanding Youth Science Foundation of China 30425001 (to H. Shen), and National “211” Environmental Genomics Grant (to D. Lu).
PY - 2008/7
Y1 - 2008/7
N2 - One-carbon metabolism facilitates the cross-talk between genetic and epigenetic processes, making it a good candidate for studying the risk of lung cancer. To investigate the role of common variants of one-carbon metabolizing genes on lung cancer risk, total 25 single nucleotide polymorphisms (SNPs) in 7 genes were genotyped among 500 incident lung cancer patients and 517 cancer-free controls. An increased risk was suggested for the variant allele carriers of MTHFR rs17037396 [odds ratio (OR) = 1.39, 95% confidence interval (CI): 1.00-1.94] and rs3753584 (OR = 1.46, 95% CI: 1.03-2.08), compared with subjects with wild homozygote, respectively, and the risk was more pronounced among older individuals (>60 years). In contrast, a decreased risk was observed for TYMS rs2853742 variant allele carriers (OR = 0.44, 95% CI: 0.19-0.99) and MTHFD rs2236225 variant allele carriers (OR = 0.76, 95% CI: 0.59-0.99). Haplotype analysis revealed that MTHFR "ACCACC" haplotype may contribute to the risk of lung cancer (OR = 1.49, 95% CI: 1.03-2.14, local test p value 0.032). A data mining method, multifactor dimensionality reduction (MDR), predicted a four-factor interaction model (rs1801133, rs4659731, rs2273029 and rs699517) with the lowest average prediction error (45.08%, p < 0.001). These findings suggest that genetic variants in one-carbon metabolizing genes might modulate the risk of lung cancer. Validation of these findings in larger studies is needed.
AB - One-carbon metabolism facilitates the cross-talk between genetic and epigenetic processes, making it a good candidate for studying the risk of lung cancer. To investigate the role of common variants of one-carbon metabolizing genes on lung cancer risk, total 25 single nucleotide polymorphisms (SNPs) in 7 genes were genotyped among 500 incident lung cancer patients and 517 cancer-free controls. An increased risk was suggested for the variant allele carriers of MTHFR rs17037396 [odds ratio (OR) = 1.39, 95% confidence interval (CI): 1.00-1.94] and rs3753584 (OR = 1.46, 95% CI: 1.03-2.08), compared with subjects with wild homozygote, respectively, and the risk was more pronounced among older individuals (>60 years). In contrast, a decreased risk was observed for TYMS rs2853742 variant allele carriers (OR = 0.44, 95% CI: 0.19-0.99) and MTHFD rs2236225 variant allele carriers (OR = 0.76, 95% CI: 0.59-0.99). Haplotype analysis revealed that MTHFR "ACCACC" haplotype may contribute to the risk of lung cancer (OR = 1.49, 95% CI: 1.03-2.14, local test p value 0.032). A data mining method, multifactor dimensionality reduction (MDR), predicted a four-factor interaction model (rs1801133, rs4659731, rs2273029 and rs699517) with the lowest average prediction error (45.08%, p < 0.001). These findings suggest that genetic variants in one-carbon metabolizing genes might modulate the risk of lung cancer. Validation of these findings in larger studies is needed.
KW - Case-control study
KW - Chinese population
KW - Haplotype
KW - Lung cancer
KW - MDR
KW - One-carbon metabolizing genes
KW - Polymorphism
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U2 - 10.1016/j.lungcan.2007.12.001
DO - 10.1016/j.lungcan.2007.12.001
M3 - Article
C2 - 18221821
AN - SCOPUS:45649084528
SN - 0169-5002
VL - 61
SP - 21
EP - 29
JO - Lung Cancer
JF - Lung Cancer
IS - 1
ER -