Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a chinese population

Hongyan Chen; Yuanyuan Chen; Yao Zhao; Weiwei Fan; Keke Zhou; Yanhong Liu; Liangfu Zhou; Ying Mao; Qingyi Wei; Jianfeng Xu; Daru Lu

doi:10.1093/aje/kwq457

Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a chinese population

Hongyan Chen, Yuanyuan Chen, Yao Zhao, Weiwei Fan, Keke Zhou, Yanhong Liu, Liangfu Zhou, Ying Mao, Qingyi Wei, Jianfeng Xu, Daru Lu

Epidemiology

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84 Scopus citations

Abstract

Two genome-wide association studies of glioma in European populations identified 14 genetic variants strongly associated with risk of glioma, but it is unknown whether these variants are associated with glioma risk in Asian populations. The authors genotyped these 14 variants in 976 glioma patients and 1,057 control subjects to evaluate their associations with risk of glioma, particularly high-grade glioma (glioblastoma; n = 312), in a Chinese population (2004-2009). Overall, the authors identified 3 susceptibility loci for glioma risk at 20q13.33 (RTEL1 rs6010620 (P = 2.79 × 10^-6)), 11q23.3 (PHLDB1 rs498872 (P = 3.8 × 10^-6)), and 5p15.33 (TERT rs2736100 (P = 3.69 × 10^-4)) in this study population; these loci were also associated with glioblastoma risk (20q13.33: RTEL1 rs6010620 (P = 3.57 × 10^-7); 11q23.3: PHLDB1 rs498872 (P = 7.24 × 10 ^-3); 5p15.33: TERT rs2736100 and TERT rs2736098 (P = 1.21 × 10^-4 and P = 2.84 × 10^-4, respectively)). This study provides further evidence for 3 glioma susceptibility regions at 20q13.33, 11q23.3, and 5p15.33 in Chinese populations.

Original language	English (US)
Pages (from-to)	915-922
Number of pages	8
Journal	American journal of epidemiology
Volume	173
Issue number	8
DOIs	https://doi.org/10.1093/aje/kwq457
State	Published - Apr 15 2011

Keywords

Asian continental ancestry group
association
genetic variation
genetics
genome-wide association study
glioma
polymorphism, single nucleotide

ASJC Scopus subject areas

Epidemiology

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10.1093/aje/kwq457

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@article{e94264b1331b44f5a6c950f4c5e82c82,

title = "Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a chinese population",

abstract = "Two genome-wide association studies of glioma in European populations identified 14 genetic variants strongly associated with risk of glioma, but it is unknown whether these variants are associated with glioma risk in Asian populations. The authors genotyped these 14 variants in 976 glioma patients and 1,057 control subjects to evaluate their associations with risk of glioma, particularly high-grade glioma (glioblastoma; n = 312), in a Chinese population (2004-2009). Overall, the authors identified 3 susceptibility loci for glioma risk at 20q13.33 (RTEL1 rs6010620 (P = 2.79 × 10-6)), 11q23.3 (PHLDB1 rs498872 (P = 3.8 × 10-6)), and 5p15.33 (TERT rs2736100 (P = 3.69 × 10-4)) in this study population; these loci were also associated with glioblastoma risk (20q13.33: RTEL1 rs6010620 (P = 3.57 × 10-7); 11q23.3: PHLDB1 rs498872 (P = 7.24 × 10 -3); 5p15.33: TERT rs2736100 and TERT rs2736098 (P = 1.21 × 10-4 and P = 2.84 × 10-4, respectively)). This study provides further evidence for 3 glioma susceptibility regions at 20q13.33, 11q23.3, and 5p15.33 in Chinese populations.",

keywords = "Asian continental ancestry group, association, genetic variation, genetics, genome-wide association study, glioma, polymorphism, single nucleotide",

author = "Hongyan Chen and Yuanyuan Chen and Yao Zhao and Weiwei Fan and Keke Zhou and Yanhong Liu and Liangfu Zhou and Ying Mao and Qingyi Wei and Jianfeng Xu and Daru Lu",

year = "2011",

month = apr,

day = "15",

doi = "10.1093/aje/kwq457",

language = "English (US)",

volume = "173",

pages = "915--922",

journal = "American journal of epidemiology",

issn = "0002-9262",

publisher = "Oxford University Press",

number = "8",

}

TY - JOUR

T1 - Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a chinese population

AU - Chen, Hongyan

AU - Chen, Yuanyuan

AU - Zhao, Yao

AU - Fan, Weiwei

AU - Zhou, Keke

AU - Liu, Yanhong

AU - Zhou, Liangfu

AU - Mao, Ying

AU - Wei, Qingyi

AU - Xu, Jianfeng

AU - Lu, Daru

PY - 2011/4/15

Y1 - 2011/4/15

N2 - Two genome-wide association studies of glioma in European populations identified 14 genetic variants strongly associated with risk of glioma, but it is unknown whether these variants are associated with glioma risk in Asian populations. The authors genotyped these 14 variants in 976 glioma patients and 1,057 control subjects to evaluate their associations with risk of glioma, particularly high-grade glioma (glioblastoma; n = 312), in a Chinese population (2004-2009). Overall, the authors identified 3 susceptibility loci for glioma risk at 20q13.33 (RTEL1 rs6010620 (P = 2.79 × 10-6)), 11q23.3 (PHLDB1 rs498872 (P = 3.8 × 10-6)), and 5p15.33 (TERT rs2736100 (P = 3.69 × 10-4)) in this study population; these loci were also associated with glioblastoma risk (20q13.33: RTEL1 rs6010620 (P = 3.57 × 10-7); 11q23.3: PHLDB1 rs498872 (P = 7.24 × 10 -3); 5p15.33: TERT rs2736100 and TERT rs2736098 (P = 1.21 × 10-4 and P = 2.84 × 10-4, respectively)). This study provides further evidence for 3 glioma susceptibility regions at 20q13.33, 11q23.3, and 5p15.33 in Chinese populations.

AB - Two genome-wide association studies of glioma in European populations identified 14 genetic variants strongly associated with risk of glioma, but it is unknown whether these variants are associated with glioma risk in Asian populations. The authors genotyped these 14 variants in 976 glioma patients and 1,057 control subjects to evaluate their associations with risk of glioma, particularly high-grade glioma (glioblastoma; n = 312), in a Chinese population (2004-2009). Overall, the authors identified 3 susceptibility loci for glioma risk at 20q13.33 (RTEL1 rs6010620 (P = 2.79 × 10-6)), 11q23.3 (PHLDB1 rs498872 (P = 3.8 × 10-6)), and 5p15.33 (TERT rs2736100 (P = 3.69 × 10-4)) in this study population; these loci were also associated with glioblastoma risk (20q13.33: RTEL1 rs6010620 (P = 3.57 × 10-7); 11q23.3: PHLDB1 rs498872 (P = 7.24 × 10 -3); 5p15.33: TERT rs2736100 and TERT rs2736098 (P = 1.21 × 10-4 and P = 2.84 × 10-4, respectively)). This study provides further evidence for 3 glioma susceptibility regions at 20q13.33, 11q23.3, and 5p15.33 in Chinese populations.

KW - Asian continental ancestry group

KW - association

KW - genetic variation

KW - genetics

KW - genome-wide association study

KW - glioma

KW - polymorphism, single nucleotide

UR - http://www.scopus.com/inward/record.url?scp=79953875872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953875872&partnerID=8YFLogxK

U2 - 10.1093/aje/kwq457

DO - 10.1093/aje/kwq457

M3 - Article

C2 - 21350045

AN - SCOPUS:79953875872

SN - 0002-9262

VL - 173

SP - 915

EP - 922

JO - American journal of epidemiology

JF - American journal of epidemiology

IS - 8

ER -

Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a chinese population

Abstract

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