Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection

Samuel B. Foster; Ming Lu; Daniel G. Glaze; James M Reuben; Lynnette L. Harris; Evan N. Cohen; Bang Ning Lee; Enxu Zhao; Mary E. Paul; Heidi Schwarzwald; Chivon McMullen-Jackson; Charla Clark; F. Daniel Armstrong; Pim Y. Brouwers; Tracie L. Miller; Andrew A. Colin; Gwendolyn B. Scott; Shahriar Shahzeidi; Elizabeth J. Willen; Deshratn Asthana; Steven E. Lipshultz; Bruce W. Thompson; William T. Shearer

doi:10.1016/j.clim.2012.04.004

Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection

Samuel B. Foster, Ming Lu, Daniel G. Glaze, James M Reuben, Lynnette L. Harris, Evan N. Cohen, Bang Ning Lee, Enxu Zhao, Mary E. Paul, Heidi Schwarzwald, Chivon McMullen-Jackson, Charla Clark, F. Daniel Armstrong, Pim Y. Brouwers, Tracie L. Miller, Andrew A. Colin, Gwendolyn B. Scott, Shahriar Shahzeidi, Elizabeth J. Willen, Deshratn AsthanaSteven E. Lipshultz, Bruce W. Thompson, William T. Shearer

Hematopathology

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Youth infected with HIV at birth often have sleep disturbances, neurocognitive deficits, and abnormal psychosocial function which are associated with and possibly resulted from elevated blood cytokine levels that may lead to a decreased quality of life. To identify molecular pathways that might be associated with these disorders, we evaluated 38 HIV-infected and 35 uninfected subjects over 18-months for intracellular cytokine levels, sleep patterns and duration of sleep, and neurodevelopmental abilities. HIV infection was significantly associated with alterations of intracellular pro-inflammatory cytokines (TNF-α, IFN-γ, IL-12), sleep factors (total time asleep and daytime sleep patterns), and neurocognitive factors (parent and patient reported problems with socio-emotional, behavioral, and executive functions; working memory-mental fatigue; verbal memory; and sustained concentration and vigilance. By better defining the relationships between HIV infection, sleep disturbances, and poor psychosocial behavior and neurocognition, it may be possible to provide targeted pharmacologic and procedural interventions to improve these debilitating conditions.

Original language	English (US)
Pages (from-to)	13-23
Number of pages	11
Journal	Clinical Immunology
Volume	144
Issue number	1
DOIs	https://doi.org/10.1016/j.clim.2012.04.004
State	Published - Jul 2012

Keywords

Intracellular cytokines
Neurocognition
Neurodevelopment
Path analysis
Pediatric HIV infection
Sleep behavior

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.clim.2012.04.004

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Foster, S. B., Lu, M., Glaze, D. G., Reuben, J. M., Harris, L. L., Cohen, E. N., Lee, B. N., Zhao, E., Paul, M. E., Schwarzwald, H., McMullen-Jackson, C., Clark, C., Armstrong, F. D., Brouwers, P. Y., Miller, T. L., Colin, A. A., Scott, G. B., Shahzeidi, S., Willen, E. J., ... Shearer, W. T. (2012). Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection. Clinical Immunology, 144(1), 13-23. https://doi.org/10.1016/j.clim.2012.04.004

Foster, SB, Lu, M, Glaze, DG, Reuben, JM, Harris, LL, Cohen, EN, Lee, BN, Zhao, E, Paul, ME, Schwarzwald, H, McMullen-Jackson, C, Clark, C, Armstrong, FD, Brouwers, PY, Miller, TL, Colin, AA, Scott, GB, Shahzeidi, S, Willen, EJ, Asthana, D, Lipshultz, SE, Thompson, BW & Shearer, WT 2012, 'Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection', Clinical Immunology, vol. 144, no. 1, pp. 13-23. https://doi.org/10.1016/j.clim.2012.04.004

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title = "Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection",

abstract = "Youth infected with HIV at birth often have sleep disturbances, neurocognitive deficits, and abnormal psychosocial function which are associated with and possibly resulted from elevated blood cytokine levels that may lead to a decreased quality of life. To identify molecular pathways that might be associated with these disorders, we evaluated 38 HIV-infected and 35 uninfected subjects over 18-months for intracellular cytokine levels, sleep patterns and duration of sleep, and neurodevelopmental abilities. HIV infection was significantly associated with alterations of intracellular pro-inflammatory cytokines (TNF-α, IFN-γ, IL-12), sleep factors (total time asleep and daytime sleep patterns), and neurocognitive factors (parent and patient reported problems with socio-emotional, behavioral, and executive functions; working memory-mental fatigue; verbal memory; and sustained concentration and vigilance. By better defining the relationships between HIV infection, sleep disturbances, and poor psychosocial behavior and neurocognition, it may be possible to provide targeted pharmacologic and procedural interventions to improve these debilitating conditions.",

keywords = "Intracellular cytokines, Neurocognition, Neurodevelopment, Path analysis, Pediatric HIV infection, Sleep behavior",

author = "Foster, {Samuel B.} and Ming Lu and Glaze, {Daniel G.} and Reuben, {James M} and Harris, {Lynnette L.} and Cohen, {Evan N.} and Lee, {Bang Ning} and Enxu Zhao and Paul, {Mary E.} and Heidi Schwarzwald and Chivon McMullen-Jackson and Charla Clark and Armstrong, {F. Daniel} and Brouwers, {Pim Y.} and Miller, {Tracie L.} and Colin, {Andrew A.} and Scott, {Gwendolyn B.} and Shahriar Shahzeidi and Willen, {Elizabeth J.} and Deshratn Asthana and Lipshultz, {Steven E.} and Thompson, {Bruce W.} and Shearer, {William T.}",

note = "Funding Information: We thank the following for their support of this study: National Institutes of Health National Heart, Lung & Blood Institute (grant RO1-HL075933 ); National Institute of Allergy and Infectious Diseases (grants P30 AI036211 and T32 AI007456); the General Clinical Research Center RR-00188 at Texas Children's Hospital ; Texas Children's Hospital Immunology Research Fund ; Christine Cambrice, RN, BSN, Michelle Del Ray, RN, Renee Ali, CCRP, Lawrence Angelina, BS, CPA, Lisa Himic, BA, Louis Pruitt, M.S., Janelle Allen, Janice Hopkins, M. Whitney Ward, M.S., Irene Delgado, M.S., and the parents and children in the study.",

year = "2012",

month = jul,

doi = "10.1016/j.clim.2012.04.004",

language = "English (US)",

volume = "144",

pages = "13--23",

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T1 - Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection

AU - Foster, Samuel B.

AU - Lu, Ming

AU - Glaze, Daniel G.

AU - Reuben, James M

AU - Harris, Lynnette L.

AU - Cohen, Evan N.

AU - Lee, Bang Ning

AU - Zhao, Enxu

AU - Paul, Mary E.

AU - Schwarzwald, Heidi

AU - McMullen-Jackson, Chivon

AU - Clark, Charla

AU - Armstrong, F. Daniel

AU - Brouwers, Pim Y.

AU - Miller, Tracie L.

AU - Colin, Andrew A.

AU - Scott, Gwendolyn B.

AU - Shahzeidi, Shahriar

AU - Willen, Elizabeth J.

AU - Asthana, Deshratn

AU - Lipshultz, Steven E.

AU - Thompson, Bruce W.

AU - Shearer, William T.

N1 - Funding Information: We thank the following for their support of this study: National Institutes of Health National Heart, Lung & Blood Institute (grant RO1-HL075933 ); National Institute of Allergy and Infectious Diseases (grants P30 AI036211 and T32 AI007456); the General Clinical Research Center RR-00188 at Texas Children's Hospital ; Texas Children's Hospital Immunology Research Fund ; Christine Cambrice, RN, BSN, Michelle Del Ray, RN, Renee Ali, CCRP, Lawrence Angelina, BS, CPA, Lisa Himic, BA, Louis Pruitt, M.S., Janelle Allen, Janice Hopkins, M. Whitney Ward, M.S., Irene Delgado, M.S., and the parents and children in the study.

PY - 2012/7

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N2 - Youth infected with HIV at birth often have sleep disturbances, neurocognitive deficits, and abnormal psychosocial function which are associated with and possibly resulted from elevated blood cytokine levels that may lead to a decreased quality of life. To identify molecular pathways that might be associated with these disorders, we evaluated 38 HIV-infected and 35 uninfected subjects over 18-months for intracellular cytokine levels, sleep patterns and duration of sleep, and neurodevelopmental abilities. HIV infection was significantly associated with alterations of intracellular pro-inflammatory cytokines (TNF-α, IFN-γ, IL-12), sleep factors (total time asleep and daytime sleep patterns), and neurocognitive factors (parent and patient reported problems with socio-emotional, behavioral, and executive functions; working memory-mental fatigue; verbal memory; and sustained concentration and vigilance. By better defining the relationships between HIV infection, sleep disturbances, and poor psychosocial behavior and neurocognition, it may be possible to provide targeted pharmacologic and procedural interventions to improve these debilitating conditions.

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KW - Neurodevelopment

KW - Path analysis

KW - Pediatric HIV infection

KW - Sleep behavior

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ER -

Associations of cytokines, sleep patterns, and neurocognitive function in youth with HIV infection

Abstract

Keywords

ASJC Scopus subject areas

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