Asymmetric distribution of oncogene products at mitosis

Bogdan Czerniak; Fritz Herz; Robert P. Wersto; Leopold G. Koss

Asymmetric distribution of oncogene products at mitosis

Bogdan Czerniak, Fritz Herz, Robert P. Wersto, Leopold G. Koss

Research output: Contribution to journal › Article › peer-review

Abstract

Computer-assisted image analysis was used to demonstrate in exponentially proliferating human tumor cells the uneven postmitotic apportionment of several oncogene-encoded proteins (ras p21; erbB-2 p185; fos p55; myc p62). This observation may provide the explanation for the high degree of heterogeneity of postmitotic cells and the asynchrony in cell cycle traverse of cultured cells.

Original language	English (US)
Pages (from-to)	4860-4863
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	89
Issue number	11
State	Published - 1992
Externally published	Yes

Keywords

daughter cells
flow cytometry
image analysis
postmitotic heterogeneity

ASJC Scopus subject areas

General

Cite this

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title = "Asymmetric distribution of oncogene products at mitosis",

abstract = "Computer-assisted image analysis was used to demonstrate in exponentially proliferating human tumor cells the uneven postmitotic apportionment of several oncogene-encoded proteins (ras p21; erbB-2 p185; fos p55; myc p62). This observation may provide the explanation for the high degree of heterogeneity of postmitotic cells and the asynchrony in cell cycle traverse of cultured cells.",

keywords = "daughter cells, flow cytometry, image analysis, postmitotic heterogeneity",

author = "Bogdan Czerniak and Fritz Herz and Wersto, {Robert P.} and Koss, {Leopold G.}",

year = "1992",

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pages = "4860--4863",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

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AU - Czerniak, Bogdan

AU - Herz, Fritz

AU - Wersto, Robert P.

AU - Koss, Leopold G.

PY - 1992

Y1 - 1992

N2 - Computer-assisted image analysis was used to demonstrate in exponentially proliferating human tumor cells the uneven postmitotic apportionment of several oncogene-encoded proteins (ras p21; erbB-2 p185; fos p55; myc p62). This observation may provide the explanation for the high degree of heterogeneity of postmitotic cells and the asynchrony in cell cycle traverse of cultured cells.

AB - Computer-assisted image analysis was used to demonstrate in exponentially proliferating human tumor cells the uneven postmitotic apportionment of several oncogene-encoded proteins (ras p21; erbB-2 p185; fos p55; myc p62). This observation may provide the explanation for the high degree of heterogeneity of postmitotic cells and the asynchrony in cell cycle traverse of cultured cells.

KW - daughter cells

KW - flow cytometry

KW - image analysis

KW - postmitotic heterogeneity

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M3 - Article

C2 - 1350677

AN - SCOPUS:0026653373

SN - 0027-8424

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 11

ER -

Asymmetric distribution of oncogene products at mitosis

Abstract

Keywords

ASJC Scopus subject areas

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