ATX-LPA receptor axis in inflammation and cancer

Shuying Liu; Mandi Murph; Nattapon Panupinthu; Gordon B. Mills

doi:10.4161/cc.8.22.9937

ATX-LPA receptor axis in inflammation and cancer

Shuying Liu, Mandi Murph, Nattapon Panupinthu, Gordon B. Mills

Research output: Contribution to journal › Review article › peer-review

93 Scopus citations

Abstract

Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol 3-phosphate) mediates a plethora of physiological and pathological activities via interactions with a series of high affinity G proteincoupled receptors (GPCR). Both LPA receptor family members and autotaxin (ATX/LysoPLD), the primary LPA-producing enzyme, are aberrantly expressed in many human breast cancers and several other cancer lineages. Using transgenic mice expressing either an LPA receptor or ATX, we recently demonstrated that the ATX-LPA receptor axis plays a causal role in breast tumorigenesis and cancer-related inflammation, further validating the ATX-LPA receptor axis as a rich therapeutic target in cancer.

Original language	English (US)
Pages (from-to)	3695-3701
Number of pages	7
Journal	Cell Cycle
Volume	8
Issue number	22
DOIs	https://doi.org/10.4161/cc.8.22.9937
State	Published - Nov 15 2009

Keywords

ATX
Breast cancer
Cytokines
G protein-coupled receptor
Inflammation
LPA
Target therapy

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

Access to Document

10.4161/cc.8.22.9937

Cite this

@article{2846fe92fe3541bd856e5586a57b9b76,

title = "ATX-LPA receptor axis in inflammation and cancer",

abstract = "Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol 3-phosphate) mediates a plethora of physiological and pathological activities via interactions with a series of high affinity G proteincoupled receptors (GPCR). Both LPA receptor family members and autotaxin (ATX/LysoPLD), the primary LPA-producing enzyme, are aberrantly expressed in many human breast cancers and several other cancer lineages. Using transgenic mice expressing either an LPA receptor or ATX, we recently demonstrated that the ATX-LPA receptor axis plays a causal role in breast tumorigenesis and cancer-related inflammation, further validating the ATX-LPA receptor axis as a rich therapeutic target in cancer.",

keywords = "ATX, Breast cancer, Cytokines, G protein-coupled receptor, Inflammation, LPA, Target therapy",

author = "Shuying Liu and Mandi Murph and Nattapon Panupinthu and Mills, {Gordon B.}",

year = "2009",

month = nov,

day = "15",

doi = "10.4161/cc.8.22.9937",

language = "English (US)",

volume = "8",

pages = "3695--3701",

journal = "Cell Cycle",

issn = "1538-4101",

publisher = "Landes Bioscience",

number = "22",

}

TY - JOUR

T1 - ATX-LPA receptor axis in inflammation and cancer

AU - Liu, Shuying

AU - Murph, Mandi

AU - Panupinthu, Nattapon

AU - Mills, Gordon B.

PY - 2009/11/15

Y1 - 2009/11/15

N2 - Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol 3-phosphate) mediates a plethora of physiological and pathological activities via interactions with a series of high affinity G proteincoupled receptors (GPCR). Both LPA receptor family members and autotaxin (ATX/LysoPLD), the primary LPA-producing enzyme, are aberrantly expressed in many human breast cancers and several other cancer lineages. Using transgenic mice expressing either an LPA receptor or ATX, we recently demonstrated that the ATX-LPA receptor axis plays a causal role in breast tumorigenesis and cancer-related inflammation, further validating the ATX-LPA receptor axis as a rich therapeutic target in cancer.

AB - Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol 3-phosphate) mediates a plethora of physiological and pathological activities via interactions with a series of high affinity G proteincoupled receptors (GPCR). Both LPA receptor family members and autotaxin (ATX/LysoPLD), the primary LPA-producing enzyme, are aberrantly expressed in many human breast cancers and several other cancer lineages. Using transgenic mice expressing either an LPA receptor or ATX, we recently demonstrated that the ATX-LPA receptor axis plays a causal role in breast tumorigenesis and cancer-related inflammation, further validating the ATX-LPA receptor axis as a rich therapeutic target in cancer.

KW - ATX

KW - Breast cancer

KW - Cytokines

KW - G protein-coupled receptor

KW - Inflammation

KW - LPA

KW - Target therapy

UR - http://www.scopus.com/inward/record.url?scp=70449769732&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70449769732&partnerID=8YFLogxK

U2 - 10.4161/cc.8.22.9937

DO - 10.4161/cc.8.22.9937

M3 - Review article

C2 - 19855166

AN - SCOPUS:70449769732

SN - 1538-4101

VL - 8

SP - 3695

EP - 3701

JO - Cell Cycle

JF - Cell Cycle

IS - 22

ER -

ATX-LPA receptor axis in inflammation and cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this