Abstract
Objective: Primary central nervous system non-Hodgkin lymphoma (PCNSL) is a malignant lymphoma limited to the cranial-spinal axis in the absence of systemic lymphoma. Historically, PCNSL accounts for fewer than 5% of all cases of primary intracranial neoplasms. PCNSL is rare in immunocompetent young adults. Although the prognosis for PCNSL is poor, approximately 20%-30% percent of cases achieve a cure. Methods: We report two cases of PCNSL originating in the ventricle in otherwise healthy immunocompetent young adults. Results: A 27-year-old man presented with 10 days of nausea, vomiting, and headache and was found to have a large intraventricular mass emanating from the choroid plexus with resultant hydrocephalus. He underwent placement of external ventricular drain and systemic and intrathecal chemotherapy for cytologically proven PCNSL. A 31-year-old pregnant woman presented with headaches, vision difficulties, and ataxia and was found to have a septum pellucidum mass. She underwent craniotomy and subtotal resection of the mass with subsequent systemic therapy and whole brain radiation for treatment of PCNSL. Conclusions: To our knowledge, this is the first report of primary CNS lymphoma of the choroid plexus and septum pellucidum in otherwise healthy, immunocompetent young adults.
Original language | English (US) |
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Pages (from-to) | 593.e9-593.e13 |
Journal | World Neurosurgery |
Volume | 79 |
Issue number | 3-4 |
DOIs | |
State | Published - 2013 |
Keywords
- CNS lymphoma
- Immunocompetent
- Intraventricular
- Primary choroid plexus
- Septum pellucidum
ASJC Scopus subject areas
- Surgery
- Clinical Neurology