Automated voxel-wise brain DTI analysis of fitness and aging

Zhexing Liu; Mahshid Farzinfar; Laurence M. Katz; Hongtu Zhu; Casey B. Goodlett; Guido Gerig; Martin Styner; Bonita L. Marks

doi:10.2174/1874347101206010080

Automated voxel-wise brain DTI analysis of fitness and aging

Zhexing Liu, Mahshid Farzinfar, Laurence M. Katz, Hongtu Zhu, Casey B. Goodlett, Guido Gerig, Martin Styner, Bonita L. Marks

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Diffusion Tensor Imaging (DTI) has become a widely used MR modality to investigate white matter integrity in the brain. This paper presents the application of an automated method for voxel-wise group comparisons of DTI images in a study of fitness and aging. The automated processing method consists of 3 steps: 1) preprocessing including image format converting, image quality control, eddy-current and motion artifact correction, skull stripping and tensor image estimation, 2) study-specific unbiased DTI atlas computation via diffeomorphic fluid-based and demons deformable registration and 3) voxel-wise statistical analysis via heterogeneous linear regression and a wild bootstrap technique for correcting for multiple comparisons. Our results show that this fully automated method is suitable for voxel-wise group DTI analysis. Furthermore, in older adults, the results suggest a strong link between reduced fractional anisotropy (FA) values, fitness and aging.

Original language	English (US)
Pages (from-to)	80-88
Number of pages	9
Journal	Open Medical Imaging Journal
Volume	6
DOIs	https://doi.org/10.2174/1874347101206010080
State	Published - 2012

Keywords

Aging and aerobic fitness
DTI atlas
Diffusion tensor imaging
Nonlinear warping
Voxel-wise analysis

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.2174/1874347101206010080

Cite this

@article{4ce2604ee27e4cdd8030f07ee9d24cab,

title = "Automated voxel-wise brain DTI analysis of fitness and aging",

abstract = "Diffusion Tensor Imaging (DTI) has become a widely used MR modality to investigate white matter integrity in the brain. This paper presents the application of an automated method for voxel-wise group comparisons of DTI images in a study of fitness and aging. The automated processing method consists of 3 steps: 1) preprocessing including image format converting, image quality control, eddy-current and motion artifact correction, skull stripping and tensor image estimation, 2) study-specific unbiased DTI atlas computation via diffeomorphic fluid-based and demons deformable registration and 3) voxel-wise statistical analysis via heterogeneous linear regression and a wild bootstrap technique for correcting for multiple comparisons. Our results show that this fully automated method is suitable for voxel-wise group DTI analysis. Furthermore, in older adults, the results suggest a strong link between reduced fractional anisotropy (FA) values, fitness and aging.",

keywords = "Aging and aerobic fitness, DTI atlas, Diffusion tensor imaging, Nonlinear warping, Voxel-wise analysis",

author = "Zhexing Liu and Mahshid Farzinfar and Katz, {Laurence M.} and Hongtu Zhu and Goodlett, {Casey B.} and Guido Gerig and Martin Styner and Marks, {Bonita L.}",

year = "2012",

doi = "10.2174/1874347101206010080",

language = "English (US)",

volume = "6",

pages = "80--88",

journal = "Open Medical Imaging Journal",

issn = "1874-3471",

publisher = "Bentham Science Publishers B.V.",

}

TY - JOUR

T1 - Automated voxel-wise brain DTI analysis of fitness and aging

AU - Liu, Zhexing

AU - Farzinfar, Mahshid

AU - Katz, Laurence M.

AU - Zhu, Hongtu

AU - Goodlett, Casey B.

AU - Gerig, Guido

AU - Styner, Martin

AU - Marks, Bonita L.

PY - 2012

Y1 - 2012

N2 - Diffusion Tensor Imaging (DTI) has become a widely used MR modality to investigate white matter integrity in the brain. This paper presents the application of an automated method for voxel-wise group comparisons of DTI images in a study of fitness and aging. The automated processing method consists of 3 steps: 1) preprocessing including image format converting, image quality control, eddy-current and motion artifact correction, skull stripping and tensor image estimation, 2) study-specific unbiased DTI atlas computation via diffeomorphic fluid-based and demons deformable registration and 3) voxel-wise statistical analysis via heterogeneous linear regression and a wild bootstrap technique for correcting for multiple comparisons. Our results show that this fully automated method is suitable for voxel-wise group DTI analysis. Furthermore, in older adults, the results suggest a strong link between reduced fractional anisotropy (FA) values, fitness and aging.

AB - Diffusion Tensor Imaging (DTI) has become a widely used MR modality to investigate white matter integrity in the brain. This paper presents the application of an automated method for voxel-wise group comparisons of DTI images in a study of fitness and aging. The automated processing method consists of 3 steps: 1) preprocessing including image format converting, image quality control, eddy-current and motion artifact correction, skull stripping and tensor image estimation, 2) study-specific unbiased DTI atlas computation via diffeomorphic fluid-based and demons deformable registration and 3) voxel-wise statistical analysis via heterogeneous linear regression and a wild bootstrap technique for correcting for multiple comparisons. Our results show that this fully automated method is suitable for voxel-wise group DTI analysis. Furthermore, in older adults, the results suggest a strong link between reduced fractional anisotropy (FA) values, fitness and aging.

KW - Aging and aerobic fitness

KW - DTI atlas

KW - Diffusion tensor imaging

KW - Nonlinear warping

KW - Voxel-wise analysis

UR - http://www.scopus.com/inward/record.url?scp=84862180357&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862180357&partnerID=8YFLogxK

U2 - 10.2174/1874347101206010080

DO - 10.2174/1874347101206010080

M3 - Article

AN - SCOPUS:84862180357

SN - 1874-3471

VL - 6

SP - 80

EP - 88

JO - Open Medical Imaging Journal

JF - Open Medical Imaging Journal

ER -

Automated voxel-wise brain DTI analysis of fitness and aging

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this