Autophagy degrades hypoxia inducible factors

Adela DePavia; Eric Jonasch; Xian De Liu

doi:10.1080/23723556.2015.1104428

Autophagy degrades hypoxia inducible factors

Adela DePavia, Eric Jonasch, Xian De Liu

Genitourinary Medical Oncology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Hypoxia inducible factors are subjected to degradation by the ubiquitin-proteasome system (UPS), macroautophagy, and chaperone-mediated autophagy. The E3 ligases, ubiquitination, autophagy receptor proteins, and oxygen are determinants that direct hypoxia-inducible factors to different degradation pathways.

Original language	English (US)
Article number	e1104428
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	2
DOIs	https://doi.org/10.1080/23723556.2015.1104428
State	Published - Mar 3 2016

Keywords

CMA
HIF1α
HIFα
UPS
macroautophagy

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.1080/23723556.2015.1104428

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title = "Autophagy degrades hypoxia inducible factors",

abstract = "Hypoxia inducible factors are subjected to degradation by the ubiquitin-proteasome system (UPS), macroautophagy, and chaperone-mediated autophagy. The E3 ligases, ubiquitination, autophagy receptor proteins, and oxygen are determinants that direct hypoxia-inducible factors to different degradation pathways.",

keywords = "CMA, HIF1α, HIFα, UPS, macroautophagy",

author = "Adela DePavia and Eric Jonasch and Liu, {Xian De}",

note = "Publisher Copyright: {\textcopyright} 2016, {\textcopyright} 2016 Taylor & Francis Group, LLC.",

year = "2016",

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AU - Jonasch, Eric

AU - Liu, Xian De

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KW - HIFα

KW - UPS

KW - macroautophagy

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Autophagy degrades hypoxia inducible factors

Abstract

Keywords

ASJC Scopus subject areas

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