Autophagy-mediated regulation of macrophages and its applications for cancer

Peiwen Chen; Matilde Cescon; Paolo Bonaldo

doi:10.4161/auto.26927

Autophagy-mediated regulation of macrophages and its applications for cancer

Peiwen Chen, Matilde Cescon, Paolo Bonaldo

Cancer Biology

Research output: Contribution to journal › Review article › peer-review

140 Scopus citations

Abstract

Autophagy is a highly conserved homeostatic pathway that plays an important role in tumor development and progression by acting on cancer cells in a cell-autonomous mechanism. However, the solid tumor is not an island, but rather an ensemble performance that includes nonmalignant stromal cells, such as macrophages. A growing body of evidence indicates that autophagy is a key component of the innate immune response. In this review, we discuss the role of autophagy in the control of macrophage production at different stages (including hematopoietic stem cell maintenance, monocyte/macrophage migration, and monocyte differentiation into macrophages) and polarization and discuss how modulating autophagy in tumor-associated macrophages (TAMs) may represent a promising strategy for limiting cancer growth and progression.

Original language	English (US)
Pages (from-to)	192-200
Number of pages	9
Journal	Autophagy
Volume	10
Issue number	2
DOIs	https://doi.org/10.4161/auto.26927
State	Published - Feb 2014

Keywords

Autophagy
Cancer
Macrophage polarization
Macrophage production
Tumor-associated macrophages

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.4161/auto.26927

Cite this

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title = "Autophagy-mediated regulation of macrophages and its applications for cancer",

abstract = "Autophagy is a highly conserved homeostatic pathway that plays an important role in tumor development and progression by acting on cancer cells in a cell-autonomous mechanism. However, the solid tumor is not an island, but rather an ensemble performance that includes nonmalignant stromal cells, such as macrophages. A growing body of evidence indicates that autophagy is a key component of the innate immune response. In this review, we discuss the role of autophagy in the control of macrophage production at different stages (including hematopoietic stem cell maintenance, monocyte/macrophage migration, and monocyte differentiation into macrophages) and polarization and discuss how modulating autophagy in tumor-associated macrophages (TAMs) may represent a promising strategy for limiting cancer growth and progression.",

keywords = "Autophagy, Cancer, Macrophage polarization, Macrophage production, Tumor-associated macrophages",

author = "Peiwen Chen and Matilde Cescon and Paolo Bonaldo",

note = "Funding Information: We apologize to the authors whose papers we could not cite because of space limitations. This work was supported by the Italian Ministry of Education, University and Research, the Cariparo Foundation, and the University of Padova.",

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T1 - Autophagy-mediated regulation of macrophages and its applications for cancer

AU - Chen, Peiwen

AU - Cescon, Matilde

AU - Bonaldo, Paolo

N1 - Funding Information: We apologize to the authors whose papers we could not cite because of space limitations. This work was supported by the Italian Ministry of Education, University and Research, the Cariparo Foundation, and the University of Padova.

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N2 - Autophagy is a highly conserved homeostatic pathway that plays an important role in tumor development and progression by acting on cancer cells in a cell-autonomous mechanism. However, the solid tumor is not an island, but rather an ensemble performance that includes nonmalignant stromal cells, such as macrophages. A growing body of evidence indicates that autophagy is a key component of the innate immune response. In this review, we discuss the role of autophagy in the control of macrophage production at different stages (including hematopoietic stem cell maintenance, monocyte/macrophage migration, and monocyte differentiation into macrophages) and polarization and discuss how modulating autophagy in tumor-associated macrophages (TAMs) may represent a promising strategy for limiting cancer growth and progression.

AB - Autophagy is a highly conserved homeostatic pathway that plays an important role in tumor development and progression by acting on cancer cells in a cell-autonomous mechanism. However, the solid tumor is not an island, but rather an ensemble performance that includes nonmalignant stromal cells, such as macrophages. A growing body of evidence indicates that autophagy is a key component of the innate immune response. In this review, we discuss the role of autophagy in the control of macrophage production at different stages (including hematopoietic stem cell maintenance, monocyte/macrophage migration, and monocyte differentiation into macrophages) and polarization and discuss how modulating autophagy in tumor-associated macrophages (TAMs) may represent a promising strategy for limiting cancer growth and progression.

KW - Autophagy

KW - Cancer

KW - Macrophage polarization

KW - Macrophage production

KW - Tumor-associated macrophages

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Autophagy-mediated regulation of macrophages and its applications for cancer

Abstract

Keywords

ASJC Scopus subject areas

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