Awakening the immune system with radiation: Optimal dose and fractionation

Saumil J. Gandhi; Andy J. Minn; Robert H. Vonderheide; E. John Wherry; Stephen M. Hahn; Amit Maity

doi:10.1016/j.canlet.2015.03.024

Awakening the immune system with radiation: Optimal dose and fractionation

Saumil J. Gandhi, Andy J. Minn, Robert H. Vonderheide, E. John Wherry, Stephen M. Hahn, Amit Maity

Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

94 Scopus citations

Abstract

The importance of ionizing radiation has historically been limited to achieving local control of tumor cells. However, emerging evidence over the last decade suggests an increasingly important role for radiation in amplifying the antitumor immune response elicited by immunomodulatory agents. Combination of radiation with immunotherapy has been shown to elicit powerful systemic responses in several pre-clinical tumor models. Additionally, recent clinical observations support the use of radiation therapy for augmenting antitumor immunity in the metastatic setting. However, radiation dose and fractionation schedules for optimal synergy between radiotherapy and immunotherapy are not well defined. Here we review pre-clinical and clinical data relating to radiation dose and fractionation in the setting of immunotherapy and discuss optimal strategies for combining the two therapies.

Original language	English (US)
Pages (from-to)	185-190
Number of pages	6
Journal	Cancer Letters
Volume	368
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2015.03.024
State	Published - Nov 28 2015

Keywords

Dose
Fractionation
Immunotherapy
Radiation

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2015.03.024

Cite this

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title = "Awakening the immune system with radiation: Optimal dose and fractionation",

abstract = "The importance of ionizing radiation has historically been limited to achieving local control of tumor cells. However, emerging evidence over the last decade suggests an increasingly important role for radiation in amplifying the antitumor immune response elicited by immunomodulatory agents. Combination of radiation with immunotherapy has been shown to elicit powerful systemic responses in several pre-clinical tumor models. Additionally, recent clinical observations support the use of radiation therapy for augmenting antitumor immunity in the metastatic setting. However, radiation dose and fractionation schedules for optimal synergy between radiotherapy and immunotherapy are not well defined. Here we review pre-clinical and clinical data relating to radiation dose and fractionation in the setting of immunotherapy and discuss optimal strategies for combining the two therapies.",

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AU - Gandhi, Saumil J.

AU - Minn, Andy J.

AU - Vonderheide, Robert H.

AU - Wherry, E. John

AU - Hahn, Stephen M.

AU - Maity, Amit

PY - 2015/11/28

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AB - The importance of ionizing radiation has historically been limited to achieving local control of tumor cells. However, emerging evidence over the last decade suggests an increasingly important role for radiation in amplifying the antitumor immune response elicited by immunomodulatory agents. Combination of radiation with immunotherapy has been shown to elicit powerful systemic responses in several pre-clinical tumor models. Additionally, recent clinical observations support the use of radiation therapy for augmenting antitumor immunity in the metastatic setting. However, radiation dose and fractionation schedules for optimal synergy between radiotherapy and immunotherapy are not well defined. Here we review pre-clinical and clinical data relating to radiation dose and fractionation in the setting of immunotherapy and discuss optimal strategies for combining the two therapies.

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KW - Fractionation

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Awakening the immune system with radiation: Optimal dose and fractionation

Abstract

Keywords

ASJC Scopus subject areas

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