Awakening the immune system with radiation: Optimal dose and fractionation

Saumil J. Gandhi, Andy J. Minn, Robert H. Vonderheide, E. John Wherry, Stephen M. Hahn, Amit Maity

Research output: Contribution to journalShort survey

43 Citations (Scopus)

Abstract

The importance of ionizing radiation has historically been limited to achieving local control of tumor cells. However, emerging evidence over the last decade suggests an increasingly important role for radiation in amplifying the antitumor immune response elicited by immunomodulatory agents. Combination of radiation with immunotherapy has been shown to elicit powerful systemic responses in several pre-clinical tumor models. Additionally, recent clinical observations support the use of radiation therapy for augmenting antitumor immunity in the metastatic setting. However, radiation dose and fractionation schedules for optimal synergy between radiotherapy and immunotherapy are not well defined. Here we review pre-clinical and clinical data relating to radiation dose and fractionation in the setting of immunotherapy and discuss optimal strategies for combining the two therapies.

Original languageEnglish (US)
Pages (from-to)185-190
Number of pages6
JournalCancer Letters
Volume368
Issue number2
DOIs
StatePublished - Nov 28 2015

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Dose Fractionation
Immune System
Immunotherapy
Radiation
Radiotherapy
Ionizing Radiation
Immunity
Neoplasms
Appointments and Schedules

Keywords

  • Dose
  • Fractionation
  • Immunotherapy
  • Radiation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Awakening the immune system with radiation : Optimal dose and fractionation. / Gandhi, Saumil J.; Minn, Andy J.; Vonderheide, Robert H.; Wherry, E. John; Hahn, Stephen M.; Maity, Amit.

In: Cancer Letters, Vol. 368, No. 2, 28.11.2015, p. 185-190.

Research output: Contribution to journalShort survey

Gandhi, Saumil J. ; Minn, Andy J. ; Vonderheide, Robert H. ; Wherry, E. John ; Hahn, Stephen M. ; Maity, Amit. / Awakening the immune system with radiation : Optimal dose and fractionation. In: Cancer Letters. 2015 ; Vol. 368, No. 2. pp. 185-190.
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