B-cell acute lymphoblastic leukemia/lymphoma in relapse presenting as a cervical mass: A case report and review of literature

Jamil Kazma; Cynae Johnson; Nitin Jain; Vasantha Lakshmi Gali; Ken H. Young; Amir A. Jazaeri

doi:10.1016/j.gore.2019.08.003

B-cell acute lymphoblastic leukemia/lymphoma in relapse presenting as a cervical mass: A case report and review of literature

Jamil Kazma, Cynae Johnson, Nitin Jain, Vasantha Lakshmi Gali, Ken H. Young, Amir A. Jazaeri

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4 Scopus citations

Abstract

The involvement of the cervix as a site of relapse for hematologic malignancies is rare. We herein present a case of relapsed B-cell Acute Lymphoblastic Leukemia/Lymphoma (ALL) mimicking advanced cervical cancer. The patient is a 61-year-old female with history B-cell ALL and had multiple relapses confined to the bone marrow and had received several different chemotherapy regimens. She presented with lower abdominal pain after the end of her last cycle for which an MRI abdomen and pelvis was done and it showed the presence of an asymmetrical cervical mass. Further imaging included a PET-CT showing the presence of hypermetabolic cervical mass with left pelvic and retroperitoneal lymph node involvement. She underwent a biopsy of 3 distinct lesions in the cervix and vagina and a diagnosis of relapsed B-cell ALL was confirmed in two out of the three specimens.

Original language	English (US)
Pages (from-to)	94-97
Number of pages	4
Journal	Gynecologic Oncology Reports
Volume	29
DOIs	https://doi.org/10.1016/j.gore.2019.08.003
State	Published - Aug 2019

Keywords

Cervical cancer
Diagnosis - relapse
Hematologic malignancy

ASJC Scopus subject areas

Oncology
Obstetrics and Gynecology

MD Anderson CCSG core facilities

Clinical Trials Office

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10.1016/j.gore.2019.08.003

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title = "B-cell acute lymphoblastic leukemia/lymphoma in relapse presenting as a cervical mass: A case report and review of literature",

abstract = "The involvement of the cervix as a site of relapse for hematologic malignancies is rare. We herein present a case of relapsed B-cell Acute Lymphoblastic Leukemia/Lymphoma (ALL) mimicking advanced cervical cancer. The patient is a 61-year-old female with history B-cell ALL and had multiple relapses confined to the bone marrow and had received several different chemotherapy regimens. She presented with lower abdominal pain after the end of her last cycle for which an MRI abdomen and pelvis was done and it showed the presence of an asymmetrical cervical mass. Further imaging included a PET-CT showing the presence of hypermetabolic cervical mass with left pelvic and retroperitoneal lymph node involvement. She underwent a biopsy of 3 distinct lesions in the cervix and vagina and a diagnosis of relapsed B-cell ALL was confirmed in two out of the three specimens.",

keywords = "Cervical cancer, Diagnosis - relapse, Hematologic malignancy",

author = "Jamil Kazma and Cynae Johnson and Nitin Jain and Gali, {Vasantha Lakshmi} and Young, {Ken H.} and Jazaeri, {Amir A.}",

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year = "2019",

month = aug,

doi = "10.1016/j.gore.2019.08.003",

language = "English (US)",

volume = "29",

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T2 - A case report and review of literature

AU - Kazma, Jamil

AU - Johnson, Cynae

AU - Jain, Nitin

AU - Gali, Vasantha Lakshmi

AU - Young, Ken H.

AU - Jazaeri, Amir A.

PY - 2019/8

Y1 - 2019/8

N2 - The involvement of the cervix as a site of relapse for hematologic malignancies is rare. We herein present a case of relapsed B-cell Acute Lymphoblastic Leukemia/Lymphoma (ALL) mimicking advanced cervical cancer. The patient is a 61-year-old female with history B-cell ALL and had multiple relapses confined to the bone marrow and had received several different chemotherapy regimens. She presented with lower abdominal pain after the end of her last cycle for which an MRI abdomen and pelvis was done and it showed the presence of an asymmetrical cervical mass. Further imaging included a PET-CT showing the presence of hypermetabolic cervical mass with left pelvic and retroperitoneal lymph node involvement. She underwent a biopsy of 3 distinct lesions in the cervix and vagina and a diagnosis of relapsed B-cell ALL was confirmed in two out of the three specimens.

AB - The involvement of the cervix as a site of relapse for hematologic malignancies is rare. We herein present a case of relapsed B-cell Acute Lymphoblastic Leukemia/Lymphoma (ALL) mimicking advanced cervical cancer. The patient is a 61-year-old female with history B-cell ALL and had multiple relapses confined to the bone marrow and had received several different chemotherapy regimens. She presented with lower abdominal pain after the end of her last cycle for which an MRI abdomen and pelvis was done and it showed the presence of an asymmetrical cervical mass. Further imaging included a PET-CT showing the presence of hypermetabolic cervical mass with left pelvic and retroperitoneal lymph node involvement. She underwent a biopsy of 3 distinct lesions in the cervix and vagina and a diagnosis of relapsed B-cell ALL was confirmed in two out of the three specimens.

KW - Cervical cancer

KW - Diagnosis - relapse

KW - Hematologic malignancy

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ER -

B-cell acute lymphoblastic leukemia/lymphoma in relapse presenting as a cervical mass: A case report and review of literature

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

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