TY - JOUR
T1 - B Cells as an immune-regulatory signature in ovarian Cancer
AU - Gupta, Prachi
AU - Chen, Changliang
AU - Chaluvally-Raghavan, Pradeep
AU - Pradeep, Sunila
N1 - Publisher Copyright:
© 2019 by the authors.
PY - 2019/7
Y1 - 2019/7
N2 - Increasing evidence suggests that the immune system plays a dynamic role in the progression of ovarian cancer, the deadliest gynecological malignancy worldwide. Accumulation of tumor-infiltrating lymphocytes has been associated with increased survival in ovarian cancer patients, and diverse interactions among immune cells in the tumor microenvironment determine tumor progression. While the regulatory functions of T cells among tumor-infiltrating lymphocytes are well defined and also involve therapeutic interventions, the role of B cells in ovarian cancer progression is still limited to their impact on survival. Recent studies have identified both pro- and anti-tumor responses of B cells in solid tumors, as different subsets of B cells play diverse roles in progression. Thus, in-depth characterization of B cell subtypes in each disease stage is crucial for understanding the importance and therapeutic potential of these cells in ovarian cancer. In this review, we summarize current knowledge about B cells in ovarian cancer and discuss emerging therapeutic interventions that could harness B cells to combat this deadly disease.
AB - Increasing evidence suggests that the immune system plays a dynamic role in the progression of ovarian cancer, the deadliest gynecological malignancy worldwide. Accumulation of tumor-infiltrating lymphocytes has been associated with increased survival in ovarian cancer patients, and diverse interactions among immune cells in the tumor microenvironment determine tumor progression. While the regulatory functions of T cells among tumor-infiltrating lymphocytes are well defined and also involve therapeutic interventions, the role of B cells in ovarian cancer progression is still limited to their impact on survival. Recent studies have identified both pro- and anti-tumor responses of B cells in solid tumors, as different subsets of B cells play diverse roles in progression. Thus, in-depth characterization of B cell subtypes in each disease stage is crucial for understanding the importance and therapeutic potential of these cells in ovarian cancer. In this review, we summarize current knowledge about B cells in ovarian cancer and discuss emerging therapeutic interventions that could harness B cells to combat this deadly disease.
KW - B cells
KW - Immune cells
KW - Ovarian cancer
KW - Tumor infiltrating lymphocytes
KW - Tumor microenvironment
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U2 - 10.3390/cancers11070894
DO - 10.3390/cancers11070894
M3 - Review article
C2 - 31248034
AN - SCOPUS:85068665327
SN - 2072-6694
VL - 11
JO - Cancers
JF - Cancers
IS - 7
M1 - 894
ER -