Baclofen, a treatment for chronic hiccup

Paul Walker; Sharon Watanabe; Eduardo Bruera

doi:10.1016/S0885-3924(98)00039-6

Baclofen, a treatment for chronic hiccup

Paul Walker, Sharon Watanabe, Eduardo Bruera

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

The efficacy of baclofen in the treatment of chronic hiccup is demonstrated in two cases. These cases highlight the present state of knowledge related to hiccup. This discussion focuses on the definition and classification of hiccup, etiologies, postulated theories to explain its function, the few studies performed to date, and non-pharmacologic and pharmacologic treatment. Baclofen appears to be the agent most efficacious in the treatment of chronic hiccup. Its commonest side effect is sedation; insomnia, dizziness, weakness, ataxia, and confusion also can occur. Following regular use, abrupt discontinuation can lead to withdrawal symptoms, such as seizure, and gradual discontinuation is recommended.

Original language	English (US)
Pages (from-to)	125-132
Number of pages	8
Journal	Journal of pain and symptom management
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/S0885-3924(98)00039-6
State	Published - Aug 1998

Keywords

Baclofen
Hiccough
Hiccup
Singultus

ASJC Scopus subject areas

General Nursing
Clinical Neurology
Anesthesiology and Pain Medicine

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10.1016/S0885-3924(98)00039-6

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abstract = "The efficacy of baclofen in the treatment of chronic hiccup is demonstrated in two cases. These cases highlight the present state of knowledge related to hiccup. This discussion focuses on the definition and classification of hiccup, etiologies, postulated theories to explain its function, the few studies performed to date, and non-pharmacologic and pharmacologic treatment. Baclofen appears to be the agent most efficacious in the treatment of chronic hiccup. Its commonest side effect is sedation; insomnia, dizziness, weakness, ataxia, and confusion also can occur. Following regular use, abrupt discontinuation can lead to withdrawal symptoms, such as seizure, and gradual discontinuation is recommended.",

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Baclofen, a treatment for chronic hiccup

Abstract

Keywords

ASJC Scopus subject areas

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