Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage

Jun Xia; Li Ya Chiu; Ralf B. Nehring; María Angélica Bravo Núñez; Qian Mei; Mercedes Perez; Yin Zhai; Devon M. Fitzgerald; John P. Pribis; Yumeng Wang; Chenyue W. Hu; Reid T. Powell; Sandra A. LaBonte; Ali Jalali; Meztli L. Matadamas Guzmán; Alfred M. Lentzsch; Adam T. Szafran; Mohan C. Joshi; Megan Richters; Janet L. Gibson; Ryan L. Frisch; P. J. Hastings; David Bates; Christine Queitsch; Susan G. Hilsenbeck; Cristian Coarfa; James C. Hu; Deborah A. Siegele; Kenneth L. Scott; Han Liang; Michael A. Mancini; Christophe Herman; Kyle M. Miller; Susan M. Rosenberg

doi:10.1016/j.cell.2018.12.008

Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage

Jun Xia, Li Ya Chiu, Ralf B. Nehring, María Angélica Bravo Núñez, Qian Mei, Mercedes Perez, Yin Zhai, Devon M. Fitzgerald, John P. Pribis, Yumeng Wang, Chenyue W. Hu, Reid T. Powell, Sandra A. LaBonte, Ali Jalali, Meztli L. Matadamas Guzmán, Alfred M. Lentzsch, Adam T. Szafran, Mohan C. Joshi, Megan Richters, Janet L. GibsonRyan L. Frisch, P. J. Hastings, David Bates, Christine Queitsch, Susan G. Hilsenbeck, Cristian Coarfa, James C. Hu, Deborah A. Siegele, Kenneth L. Scott, Han Liang, Michael A. Mancini, Christophe Herman, Kyle M. Miller, Susan M. Rosenberg

Bioinformatics & Computational Biology

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

A large network of bacterial proteins promotes endogenous DNA damage and mutations when upregulated, acting like protein carcinogens, and has human homologs that form a cancer predictive network.

Original language	English (US)
Pages (from-to)	127-143.e24
Journal	Cell
Volume	176
Issue number	1-2
DOIs	https://doi.org/10.1016/j.cell.2018.12.008
State	Published - Jan 10 2019

Keywords

DNA damage response
DNA double-strand breaks
DNMT1
Escherichia coli
cancer
evolution
genome instability
human cells
microbial cancer models
replication fork reversal

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

MD Anderson CCSG core facilities

Bioinformatics Shared Resource

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10.1016/j.cell.2018.12.008

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Xia, J., Chiu, L. Y., Nehring, R. B., Bravo Núñez, M. A., Mei, Q., Perez, M., Zhai, Y., Fitzgerald, D. M., Pribis, J. P., Wang, Y., Hu, C. W., Powell, R. T., LaBonte, S. A., Jalali, A., Matadamas Guzmán, M. L., Lentzsch, A. M., Szafran, A. T., Joshi, M. C., Richters, M., ... Rosenberg, S. M. (2019). Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage. Cell, 176(1-2), 127-143.e24. https://doi.org/10.1016/j.cell.2018.12.008

Xia, J, Chiu, LY, Nehring, RB, Bravo Núñez, MA, Mei, Q, Perez, M, Zhai, Y, Fitzgerald, DM, Pribis, JP, Wang, Y, Hu, CW, Powell, RT, LaBonte, SA, Jalali, A, Matadamas Guzmán, ML, Lentzsch, AM, Szafran, AT, Joshi, MC, Richters, M, Gibson, JL, Frisch, RL, Hastings, PJ, Bates, D, Queitsch, C, Hilsenbeck, SG, Coarfa, C, Hu, JC, Siegele, DA, Scott, KL, Liang, H, Mancini, MA, Herman, C, Miller, KM & Rosenberg, SM 2019, 'Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage', Cell, vol. 176, no. 1-2, pp. 127-143.e24. https://doi.org/10.1016/j.cell.2018.12.008

@article{948f6bb5107b42e4a3c95918702730a6,

title = "Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage",

abstract = "A large network of bacterial proteins promotes endogenous DNA damage and mutations when upregulated, acting like protein carcinogens, and has human homologs that form a cancer predictive network.",

keywords = "DNA damage response, DNA double-strand breaks, DNMT1, Escherichia coli, cancer, evolution, genome instability, human cells, microbial cancer models, replication fork reversal",

author = "Jun Xia and Chiu, {Li Ya} and Nehring, {Ralf B.} and {Bravo N{\'u}{\~n}ez}, {Mar{\'i}a Ang{\'e}lica} and Qian Mei and Mercedes Perez and Yin Zhai and Fitzgerald, {Devon M.} and Pribis, {John P.} and Yumeng Wang and Hu, {Chenyue W.} and Powell, {Reid T.} and LaBonte, {Sandra A.} and Ali Jalali and {Matadamas Guzm{\'a}n}, {Meztli L.} and Lentzsch, {Alfred M.} and Szafran, {Adam T.} and Joshi, {Mohan C.} and Megan Richters and Gibson, {Janet L.} and Frisch, {Ryan L.} and Hastings, {P. J.} and David Bates and Christine Queitsch and Hilsenbeck, {Susan G.} and Cristian Coarfa and Hu, {James C.} and Siegele, {Deborah A.} and Scott, {Kenneth L.} and Han Liang and Mancini, {Michael A.} and Christophe Herman and Miller, {Kyle M.} and Rosenberg, {Susan M.}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2019",

month = jan,

day = "10",

doi = "10.1016/j.cell.2018.12.008",

language = "English (US)",

volume = "176",

pages = "127--143.e24",

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T1 - Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage

AU - Xia, Jun

AU - Chiu, Li Ya

AU - Nehring, Ralf B.

AU - Bravo Núñez, María Angélica

AU - Mei, Qian

AU - Perez, Mercedes

AU - Zhai, Yin

AU - Fitzgerald, Devon M.

AU - Pribis, John P.

AU - Wang, Yumeng

AU - Hu, Chenyue W.

AU - Powell, Reid T.

AU - LaBonte, Sandra A.

AU - Jalali, Ali

AU - Matadamas Guzmán, Meztli L.

AU - Lentzsch, Alfred M.

AU - Szafran, Adam T.

AU - Joshi, Mohan C.

AU - Richters, Megan

AU - Gibson, Janet L.

AU - Frisch, Ryan L.

AU - Hastings, P. J.

AU - Bates, David

AU - Queitsch, Christine

AU - Hilsenbeck, Susan G.

AU - Coarfa, Cristian

AU - Hu, James C.

AU - Siegele, Deborah A.

AU - Scott, Kenneth L.

AU - Liang, Han

AU - Mancini, Michael A.

AU - Herman, Christophe

AU - Miller, Kyle M.

AU - Rosenberg, Susan M.

PY - 2019/1/10

Y1 - 2019/1/10

N2 - A large network of bacterial proteins promotes endogenous DNA damage and mutations when upregulated, acting like protein carcinogens, and has human homologs that form a cancer predictive network.

AB - A large network of bacterial proteins promotes endogenous DNA damage and mutations when upregulated, acting like protein carcinogens, and has human homologs that form a cancer predictive network.

KW - DNA damage response

KW - DNA double-strand breaks

KW - DNMT1

KW - Escherichia coli

KW - cancer

KW - evolution

KW - genome instability

KW - human cells

KW - microbial cancer models

KW - replication fork reversal

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AN - SCOPUS:85059427401

SN - 0092-8674

VL - 176

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JO - Cell

JF - Cell

IS - 1-2

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Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

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