Bacteriophages as tools for vaccine development.

G. F. Hatfull; L. Barsom; L. Chang; M. Donnelly-Wu; M. H. Lee; M. Levin; C. Nesbit; G. J. Sarkis

Bacteriophages as tools for vaccine development.

G. F. Hatfull, L. Barsom, L. Chang, M. Donnelly-Wu, M. H. Lee, M. Levin, C. Nesbit, G. J. Sarkis

Molecular & Cellular Oncology

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

The construction of live recombinant bacterial vaccines requires a reasonably sophisticated genetic system for the introduction, stabilization and expression of foreign antigen genes. Bacteriophages offer a rich collection of tools that can be used for vaccine construction, including site-specific integration-proficient vectors, non-antibiotic selectable markers and signals for efficient transcription and translation of foreign genes. We describe the characterization of a temperate phage of the mycobacteria, mycobacteriophage L5, and application of these phage studies for the construction of recombinant BCG vaccines.

Original language	English (US)
Pages (from-to)	43-47
Number of pages	5
Journal	Developments in biological standardization
Volume	82
State	Published - 1994

ASJC Scopus subject areas

General Immunology and Microbiology
Drug Discovery
Public Health, Environmental and Occupational Health

Cite this

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title = "Bacteriophages as tools for vaccine development.",

abstract = "The construction of live recombinant bacterial vaccines requires a reasonably sophisticated genetic system for the introduction, stabilization and expression of foreign antigen genes. Bacteriophages offer a rich collection of tools that can be used for vaccine construction, including site-specific integration-proficient vectors, non-antibiotic selectable markers and signals for efficient transcription and translation of foreign genes. We describe the characterization of a temperate phage of the mycobacteria, mycobacteriophage L5, and application of these phage studies for the construction of recombinant BCG vaccines.",

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T1 - Bacteriophages as tools for vaccine development.

AU - Hatfull, G. F.

AU - Barsom, L.

AU - Chang, L.

AU - Donnelly-Wu, M.

AU - Lee, M. H.

AU - Levin, M.

AU - Nesbit, C.

AU - Sarkis, G. J.

N1 - Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 1994

Y1 - 1994

N2 - The construction of live recombinant bacterial vaccines requires a reasonably sophisticated genetic system for the introduction, stabilization and expression of foreign antigen genes. Bacteriophages offer a rich collection of tools that can be used for vaccine construction, including site-specific integration-proficient vectors, non-antibiotic selectable markers and signals for efficient transcription and translation of foreign genes. We describe the characterization of a temperate phage of the mycobacteria, mycobacteriophage L5, and application of these phage studies for the construction of recombinant BCG vaccines.

AB - The construction of live recombinant bacterial vaccines requires a reasonably sophisticated genetic system for the introduction, stabilization and expression of foreign antigen genes. Bacteriophages offer a rich collection of tools that can be used for vaccine construction, including site-specific integration-proficient vectors, non-antibiotic selectable markers and signals for efficient transcription and translation of foreign genes. We describe the characterization of a temperate phage of the mycobacteria, mycobacteriophage L5, and application of these phage studies for the construction of recombinant BCG vaccines.

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M3 - Review article

C2 - 7958482

AN - SCOPUS:0028189733

SN - 0301-5149

VL - 82

SP - 43

EP - 47

JO - Developments in biological standardization

JF - Developments in biological standardization

ER -

Bacteriophages as tools for vaccine development.

Abstract

ASJC Scopus subject areas

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