Abstract
The analysis of high-throughput data sets, such as microarray data, often requires that individual variables (genes, for example) be grouped into clusters of variables with highly correlated values across all samples. Gene shaving is an established method for generating such clusters, but is overly sensitive to the input data: changing just one sample can determine whether or not an entire cluster is found. This paper describes a clustering method based on the bootstrap aggregation of gene shaving clusters, which overcomes this and other problems, and applies the new method to a large gene expression microarray dataset from brain tumour samples.
Original language | English (US) |
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Pages (from-to) | 326-343 |
Number of pages | 18 |
Journal | International Journal of Bioinformatics Research and Applications |
Volume | 6 |
Issue number | 4 |
DOIs | |
State | Published - Oct 2010 |
Keywords
- Bootstrap aggregation
- Clustering
- Gene shaving
- Glioblastoma
ASJC Scopus subject areas
- Biomedical Engineering
- Health Informatics
- Clinical Biochemistry
- Health Information Management
MD Anderson CCSG core facilities
- Bioinformatics Shared Resource
- Biostatistics Resource Group