Ball lens coupled fiber-optic probe for depthresolved spectroscopy of epithelial tissue

Richard A. Schwarz; Dizem Arifler; Sung K. Chang; Ina Pavlova; Insiya A. Hussain; Vivian Mack; Bob Knight; Rebecca Richards-Kortum; Ann M. Gillenwater

doi:10.1364/OL.30.001159

Ball lens coupled fiber-optic probe for depthresolved spectroscopy of epithelial tissue

Richard A. Schwarz, Dizem Arifler, Sung K. Chang, Ina Pavlova, Insiya A. Hussain, Vivian Mack, Bob Knight, Rebecca Richards-Kortum, Ann M. Gillenwater

Head & Neck Surgery

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61 Scopus citations

Abstract

A ball lens coupled fiber-optic probe design is described for depth-resolved measurements of the fluorescence and reflectance properties of epithelial tissue. A reflectance target, fluorescence targets, and a two-layer tissue phantom consisting of fluorescent microspheres suspended in collagen are used to characterize the performance of the probe. Localization of the signal to within 300 μm of the probe tip is observed by use of reflectance and fluorescence targets in air. Differential enhancement of the fluorescence signal from the top layer of the two-layer tissue phantom is observed.

Original language	English (US)
Pages (from-to)	1159-1161
Number of pages	3
Journal	Optics Letters
Volume	30
Issue number	10
DOIs	https://doi.org/10.1364/OL.30.001159
State	Published - May 15 2005

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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10.1364/OL.30.001159

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title = "Ball lens coupled fiber-optic probe for depthresolved spectroscopy of epithelial tissue",

abstract = "A ball lens coupled fiber-optic probe design is described for depth-resolved measurements of the fluorescence and reflectance properties of epithelial tissue. A reflectance target, fluorescence targets, and a two-layer tissue phantom consisting of fluorescent microspheres suspended in collagen are used to characterize the performance of the probe. Localization of the signal to within 300 μm of the probe tip is observed by use of reflectance and fluorescence targets in air. Differential enhancement of the fluorescence signal from the top layer of the two-layer tissue phantom is observed.",

author = "Schwarz, {Richard A.} and Dizem Arifler and Chang, {Sung K.} and Ina Pavlova and Hussain, {Insiya A.} and Vivian Mack and Bob Knight and Rebecca Richards-Kortum and Gillenwater, {Ann M.}",

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doi = "10.1364/OL.30.001159",

language = "English (US)",

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AU - Schwarz, Richard A.

AU - Arifler, Dizem

AU - Chang, Sung K.

AU - Pavlova, Ina

AU - Hussain, Insiya A.

AU - Mack, Vivian

AU - Knight, Bob

AU - Richards-Kortum, Rebecca

AU - Gillenwater, Ann M.

PY - 2005/5/15

Y1 - 2005/5/15

N2 - A ball lens coupled fiber-optic probe design is described for depth-resolved measurements of the fluorescence and reflectance properties of epithelial tissue. A reflectance target, fluorescence targets, and a two-layer tissue phantom consisting of fluorescent microspheres suspended in collagen are used to characterize the performance of the probe. Localization of the signal to within 300 μm of the probe tip is observed by use of reflectance and fluorescence targets in air. Differential enhancement of the fluorescence signal from the top layer of the two-layer tissue phantom is observed.

AB - A ball lens coupled fiber-optic probe design is described for depth-resolved measurements of the fluorescence and reflectance properties of epithelial tissue. A reflectance target, fluorescence targets, and a two-layer tissue phantom consisting of fluorescent microspheres suspended in collagen are used to characterize the performance of the probe. Localization of the signal to within 300 μm of the probe tip is observed by use of reflectance and fluorescence targets in air. Differential enhancement of the fluorescence signal from the top layer of the two-layer tissue phantom is observed.

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JO - Optics Letters

JF - Optics Letters

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Ball lens coupled fiber-optic probe for depthresolved spectroscopy of epithelial tissue

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