Basic Science: Pain Mechanisms and Pathways

Yinan Chen; Salahadin Abdi

doi:10.1007/978-3-030-87266-3_36

Basic Science: Pain Mechanisms and Pathways

Yinan Chen, Salahadin Abdi

Pain Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Pain perception begins with nociceptors. Aδ and C fibers carry peripheral noxious stimuli to the central nervous system. First pain and second pain are transmitted to the brain separately, through spinothalamic tract, and spinoamygdalar/spinohypothalamic pathways, respectively. Descending pathways from brain to spinal cord modulate pain via inhibition or facilitation. Abnormal response to pain includes peripheral sensitization, central sensitization, and wind-up phenomenon. Understanding pain pathways and their modulations will provide basis for multimodal analgesia and chronic pain.

Original language	English (US)
Title of host publication	Anesthesiology In-Training Exam Review
Subtitle of host publication	Regional Anesthesia and Chronic Pain
Publisher	Springer International Publishing
Pages	185-189
Number of pages	5
ISBN (Electronic)	9783030872663
ISBN (Print)	9783030872656
DOIs	https://doi.org/10.1007/978-3-030-87266-3_36
State	Published - Jan 1 2022

ASJC Scopus subject areas

General Medicine

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10.1007/978-3-030-87266-3_36

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AB - Pain perception begins with nociceptors. Aδ and C fibers carry peripheral noxious stimuli to the central nervous system. First pain and second pain are transmitted to the brain separately, through spinothalamic tract, and spinoamygdalar/spinohypothalamic pathways, respectively. Descending pathways from brain to spinal cord modulate pain via inhibition or facilitation. Abnormal response to pain includes peripheral sensitization, central sensitization, and wind-up phenomenon. Understanding pain pathways and their modulations will provide basis for multimodal analgesia and chronic pain.

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Basic Science: Pain Mechanisms and Pathways

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