TY - JOUR
T1 - Beam path toxicity in candidate organs-at-risk
T2 - Assessment of radiation emetogenesis for patients receiving head and neck intensity modulated radiotherapy
AU - Kocak-Uzel, Esengul
AU - Gunn, G. Brandon
AU - Colen, Rivka R.
AU - Kantor, Micheal E.
AU - Mohamed, Abdallah S.R.
AU - Schoultz-Henley, Sara
AU - Mavroidis, Paniyotis
AU - Frank, Steven J.
AU - Garden, Adam S.
AU - Beadle, Beth M.
AU - Morrison, William H.
AU - Phan, Jack
AU - Rosenthal, David I.
AU - Fuller, Clifton D.
N1 - Funding Information:
Clifton D. Fuller, MD, PhD received/receives grant support from the following mechanisms: SWOG Hope Foundation Dr. Charles A. Coltman, Jr. Fellowship in Clinical Trials; the National Institutes of Health /National Cancer Institute Paul Calabresi Program in Clinical Oncology ( K12CA088084-14 ) and Clinician Scientist Loan Repayment Program ( L30 CA136381-02 ); Elekta AB/MD Anderson MR-LinAc Consortium Grant ; GE Healthcare Technologies/MD Anderson Center for Advanced Biomedical Imaging In-Kind Award ; Center for Radiation Oncology Research at MD Anderson Cancer Center Seed Grant ; and the MD Anderson Institutional Research Grant Program . These listed funders/supporters played no role in the study design, collection, analysis, interpretation of data, manuscript writing, or decision to submit the report for publication.
PY - 2014/5
Y1 - 2014/5
N2 - Background To investigate potential dose-response relationship between radiation-associated nausea and vomiting (RANV) reported during radiotherapy and candidate nausea/vomiting-associated regions of interest (CNV-ROIs) in head and neck (HNC) squamous cell carcinomas. Methods and material A total of 130 patients treated with IMRT with squamous cell carcinomas of head and neck were evaluated. For each patient, CNV-ROIs were segmented manually on planning CT images. Clinical on-treatment RANV data were reconstructed by a review of the records for all patients. Dosimetric data parameters were recorded from dose-volume histograms. Nausea and vomiting reports were concatenated as a single binary "Any N/V" variable, and as a "CTC-V2+" variable. Results The mean dose to CNV-ROIs was higher for patients experiencing RANV events. For patients receiving IMRT alone, a dose-response effect was observed with varying degrees of magnitude, at a statistically significant level for the area postrema, brainstem, dorsal vagal complex, medulla oblongata, solitary nucleus, oropharyngeal mucosa and whole brain CNV-ROIs. Conclusion RANV is a common therapy-related morbidity facing patients receiving HNC radiotherapy, and, for those receiving radiotherapy-alone, is associated with modifiable dose to specific CNS structures.
AB - Background To investigate potential dose-response relationship between radiation-associated nausea and vomiting (RANV) reported during radiotherapy and candidate nausea/vomiting-associated regions of interest (CNV-ROIs) in head and neck (HNC) squamous cell carcinomas. Methods and material A total of 130 patients treated with IMRT with squamous cell carcinomas of head and neck were evaluated. For each patient, CNV-ROIs were segmented manually on planning CT images. Clinical on-treatment RANV data were reconstructed by a review of the records for all patients. Dosimetric data parameters were recorded from dose-volume histograms. Nausea and vomiting reports were concatenated as a single binary "Any N/V" variable, and as a "CTC-V2+" variable. Results The mean dose to CNV-ROIs was higher for patients experiencing RANV events. For patients receiving IMRT alone, a dose-response effect was observed with varying degrees of magnitude, at a statistically significant level for the area postrema, brainstem, dorsal vagal complex, medulla oblongata, solitary nucleus, oropharyngeal mucosa and whole brain CNV-ROIs. Conclusion RANV is a common therapy-related morbidity facing patients receiving HNC radiotherapy, and, for those receiving radiotherapy-alone, is associated with modifiable dose to specific CNS structures.
KW - Brainstem
KW - Dorsal vagal complex
KW - Intensity modulated radiotherapy
KW - Nausea
KW - Organ-at-risk
KW - Vomiting
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U2 - 10.1016/j.radonc.2014.02.019
DO - 10.1016/j.radonc.2014.02.019
M3 - Article
C2 - 24746582
AN - SCOPUS:84902533373
SN - 0167-8140
VL - 111
SP - 281
EP - 288
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
IS - 2
ER -