Behavioural evidence for partial agonist properties of RO 15-1788, a benzodiazepine receptor antagonist

Robert Dantzer; Alain Pério

doi:10.1016/0014-2999(82)90355-7

Behavioural evidence for partial agonist properties of RO 15-1788, a benzodiazepine receptor antagonist

Robert Dantzer, Alain Pério

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

Rats trained to discriminate pentylenetetrazol from saline had this cue antagonized by the benzodiazepine, clorazepate. Ro 15-1788 reversed the antagonism of the pentylenetetrazol cue produced by clorazepate. Similarly, Ro 15-1788 blocked the anti-conflict effect of clorazepate. Rats trained to discriminate clorazepate from saline, however, generalized this cue to Ro 15-1788. These results demonstrate that Ro 15-1788 is not a pure benzodiazepine antagonist, but has partial agonist properties.

Original language	English (US)
Pages (from-to)	655-658
Number of pages	4
Journal	European Journal of Pharmacology
Volume	81
Issue number	4
DOIs	https://doi.org/10.1016/0014-2999(82)90355-7
State	Published - Jul 30 1982
Externally published	Yes

Keywords

Approach-avoidance conflict
Benzodiazepine antagonist
Clorazepate cue
Drug discrimination
Pentylenetetrazol cue

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(82)90355-7

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title = "Behavioural evidence for partial agonist properties of RO 15-1788, a benzodiazepine receptor antagonist",

abstract = "Rats trained to discriminate pentylenetetrazol from saline had this cue antagonized by the benzodiazepine, clorazepate. Ro 15-1788 reversed the antagonism of the pentylenetetrazol cue produced by clorazepate. Similarly, Ro 15-1788 blocked the anti-conflict effect of clorazepate. Rats trained to discriminate clorazepate from saline, however, generalized this cue to Ro 15-1788. These results demonstrate that Ro 15-1788 is not a pure benzodiazepine antagonist, but has partial agonist properties.",

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T1 - Behavioural evidence for partial agonist properties of RO 15-1788, a benzodiazepine receptor antagonist

AU - Dantzer, Robert

AU - Pério, Alain

PY - 1982/7/30

Y1 - 1982/7/30

N2 - Rats trained to discriminate pentylenetetrazol from saline had this cue antagonized by the benzodiazepine, clorazepate. Ro 15-1788 reversed the antagonism of the pentylenetetrazol cue produced by clorazepate. Similarly, Ro 15-1788 blocked the anti-conflict effect of clorazepate. Rats trained to discriminate clorazepate from saline, however, generalized this cue to Ro 15-1788. These results demonstrate that Ro 15-1788 is not a pure benzodiazepine antagonist, but has partial agonist properties.

AB - Rats trained to discriminate pentylenetetrazol from saline had this cue antagonized by the benzodiazepine, clorazepate. Ro 15-1788 reversed the antagonism of the pentylenetetrazol cue produced by clorazepate. Similarly, Ro 15-1788 blocked the anti-conflict effect of clorazepate. Rats trained to discriminate clorazepate from saline, however, generalized this cue to Ro 15-1788. These results demonstrate that Ro 15-1788 is not a pure benzodiazepine antagonist, but has partial agonist properties.

KW - Approach-avoidance conflict

KW - Benzodiazepine antagonist

KW - Clorazepate cue

KW - Drug discrimination

KW - Pentylenetetrazol cue

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Behavioural evidence for partial agonist properties of RO 15-1788, a benzodiazepine receptor antagonist

Abstract

Keywords

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