TY - JOUR
T1 - Benchmarks and Geographic Differences in Gallbladder Cancer Surgery
T2 - An International Multicenter Study
AU - Vega, Eduardo A.
AU - Newhook, Timothy E.
AU - Mellado, Sebastian
AU - Ruzzenente, Andrea
AU - Okuno, Masayuki
AU - De Bellis, Mario
AU - Panettieri, Elena
AU - Ahmad, M. Usman
AU - Merlo, Ignacio
AU - Rojas, Jesus
AU - De Rose, Agostino M.
AU - Nishino, Hiroto
AU - Sinnamon, Andrew J.
AU - Donadon, Matteo
AU - Hauger, Marit S.
AU - Guevara, Oscar A.
AU - Munoz, Cesar
AU - Denbo, Jason W.
AU - Chun, Yun Shin
AU - Tran Cao, Hop S.
AU - Sanchez Claria, Rodrigo
AU - Tzeng, Ching Wei D.
AU - De Aretxabala, Xabier
AU - Vivanco, Marcelo
AU - Brudvik, Kristoffer W.
AU - Seo, Satoru
AU - Pekolj, Juan
AU - Poultsides, George A.
AU - Torzilli, Guido
AU - Giuliante, Felice
AU - Anaya, Daniel A.
AU - Guglielmi, Alfredo
AU - Vinuela, Eduardo
AU - Vauthey, Jean Nicolas
N1 - Funding Information:
This study was supported by the National Cancer Institute under award number P30CA016672, which supports the MD Anderson Cancer Center Clinical Trials Support Resource. Travel grant award for the 35th Meeting of Japanese Society of Hepato-Biliary-Pancreatic Surgery.
Publisher Copyright:
© 2023, Society of Surgical Oncology.
PY - 2023/8
Y1 - 2023/8
N2 - Background: High-quality surgery plays a central role in the delivery of excellent oncologic care. Benchmark values indicate the best achievable results. We aimed to define benchmark values for gallbladder cancer (GBC) surgery across an international population. Patients and Methods: This study included consecutive patients with GBC who underwent curative-intent surgery during 2000–2021 at 13 centers, across seven countries and four continents. Patients operated on at high-volume centers without the need for vascular and/or bile duct reconstruction and without significant comorbidities were chosen as the benchmark group. Results: Of 906 patients who underwent curative-intent GBC surgery during the study period, 245 (27%) were included in the benchmark group. These were predominantly women (n = 174, 71%) and had a median age of 64 years (interquartile range 57–70 years). In the benchmark group, 50 patients (20%) experienced complications within 90 days after surgery, with 20 patients (8%) developing major complications (Clavien–Dindo grade ≥ IIIa). Median length of postoperative hospital stay was 6 days (interquartile range 4–8 days). Benchmark values included ≥ 4 lymph nodes retrieved, estimated intraoperative blood loss ≤ 350 mL, perioperative blood transfusion rate ≤ 13%, operative time ≤ 332 min, length of hospital stay ≤ 8 days, R1 margin rate ≤ 7%, complication rate ≤ 22%, and rate of grade ≥ IIIa complications ≤ 11%. Conclusions: Surgery for GBC remains associated with significant morbidity. The availability of benchmark values may facilitate comparisons in future analyses among GBC patients, GBC surgical approaches, and centers performing GBC surgery.
AB - Background: High-quality surgery plays a central role in the delivery of excellent oncologic care. Benchmark values indicate the best achievable results. We aimed to define benchmark values for gallbladder cancer (GBC) surgery across an international population. Patients and Methods: This study included consecutive patients with GBC who underwent curative-intent surgery during 2000–2021 at 13 centers, across seven countries and four continents. Patients operated on at high-volume centers without the need for vascular and/or bile duct reconstruction and without significant comorbidities were chosen as the benchmark group. Results: Of 906 patients who underwent curative-intent GBC surgery during the study period, 245 (27%) were included in the benchmark group. These were predominantly women (n = 174, 71%) and had a median age of 64 years (interquartile range 57–70 years). In the benchmark group, 50 patients (20%) experienced complications within 90 days after surgery, with 20 patients (8%) developing major complications (Clavien–Dindo grade ≥ IIIa). Median length of postoperative hospital stay was 6 days (interquartile range 4–8 days). Benchmark values included ≥ 4 lymph nodes retrieved, estimated intraoperative blood loss ≤ 350 mL, perioperative blood transfusion rate ≤ 13%, operative time ≤ 332 min, length of hospital stay ≤ 8 days, R1 margin rate ≤ 7%, complication rate ≤ 22%, and rate of grade ≥ IIIa complications ≤ 11%. Conclusions: Surgery for GBC remains associated with significant morbidity. The availability of benchmark values may facilitate comparisons in future analyses among GBC patients, GBC surgical approaches, and centers performing GBC surgery.
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U2 - 10.1245/s10434-023-13531-2
DO - 10.1245/s10434-023-13531-2
M3 - Article
C2 - 37149547
AN - SCOPUS:85158154735
SN - 1068-9265
VL - 30
SP - 4904
EP - 4911
JO - Annals of surgical oncology
JF - Annals of surgical oncology
IS - 8
ER -