Beyond bacteria: How the intratumor mycobiome modulates lung adenocarcinoma progression

Zahraa Rahal; Humam Kadara

doi:10.1016/j.ccell.2023.09.002

Beyond bacteria: How the intratumor mycobiome modulates lung adenocarcinoma progression

Zahraa Rahal, Humam Kadara

Translational Molecular Pathology

Research output: Contribution to journal › Comment/debate › peer-review

1 Scopus citations

Abstract

Increasing evidence suggests that tumors harbor diverse microbiomes, adding complexity to the tumor microenvironment. In this issue of Cancer Cell, Liu et al. highlight the role of the intratumor mycobiome, specifically Aspergillus sydowii, in promoting lung adenocarcinoma progression. A. sydowii enhances the recruitment and activation of myeloid-derived suppressor cells via IL-1β signaling driven by the β-glucan-mediated Dectin-1/CARD9 pathway.

Original language	English (US)
Pages (from-to)	1846-1848
Number of pages	3
Journal	Cancer cell
Volume	41
Issue number	11
DOIs	https://doi.org/10.1016/j.ccell.2023.09.002
State	Published - Nov 13 2023

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.ccell.2023.09.002

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title = "Beyond bacteria: How the intratumor mycobiome modulates lung adenocarcinoma progression",

abstract = "Increasing evidence suggests that tumors harbor diverse microbiomes, adding complexity to the tumor microenvironment. In this issue of Cancer Cell, Liu et al. highlight the role of the intratumor mycobiome, specifically Aspergillus sydowii, in promoting lung adenocarcinoma progression. A. sydowii enhances the recruitment and activation of myeloid-derived suppressor cells via IL-1β signaling driven by the β-glucan-mediated Dectin-1/CARD9 pathway.",

author = "Zahraa Rahal and Humam Kadara",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2023",

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AU - Kadara, Humam

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N2 - Increasing evidence suggests that tumors harbor diverse microbiomes, adding complexity to the tumor microenvironment. In this issue of Cancer Cell, Liu et al. highlight the role of the intratumor mycobiome, specifically Aspergillus sydowii, in promoting lung adenocarcinoma progression. A. sydowii enhances the recruitment and activation of myeloid-derived suppressor cells via IL-1β signaling driven by the β-glucan-mediated Dectin-1/CARD9 pathway.

AB - Increasing evidence suggests that tumors harbor diverse microbiomes, adding complexity to the tumor microenvironment. In this issue of Cancer Cell, Liu et al. highlight the role of the intratumor mycobiome, specifically Aspergillus sydowii, in promoting lung adenocarcinoma progression. A. sydowii enhances the recruitment and activation of myeloid-derived suppressor cells via IL-1β signaling driven by the β-glucan-mediated Dectin-1/CARD9 pathway.

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Beyond bacteria: How the intratumor mycobiome modulates lung adenocarcinoma progression

Abstract

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