Abstract
The traditional understanding that proteins are the only effectors of gene function has been challenged by the discovery of a group of genes that do not encode proteins (non-coding genes [ncGs]). The role of ncGs in the pathogenesis and potentially the treatment of several human diseases is increasingly being confirmed. A robust collection of literature exists to support the theory of the involvement of ncGs and their non-coding RNA (ncRNA) transcripts in the pathogenesis of cancer. This review focuses on the role of ncRNAs in human carcinogenesis and describes why deciphering the function of these RNAs might lead to the development of new anticancer drugs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 350-358 |
| Number of pages | 9 |
| Journal | Current Opinion in Drug Discovery and Development |
| Volume | 13 |
| Issue number | 3 |
| State | Published - May 2010 |
Keywords
- Cancer
- microRNA
- non-coding RNA
- oncogene
- piRNA
- tumor suppressor gene
- ultraconserved region
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery