Abstract
For development of a new ligand-directed pharmacology, it is critical to measure delivery of targeted drug ligands via molecular imaging or diagnostic readouts (termed theranostics). Combinatorial peptide libraries serve as unbiased functional screens that can identify specific peptides targeting cell-surface receptors accessible to the circulation. As candidate drug leads, such peptides provide motifs likely to modify ligand-receptor interactions and downstream signal transduction pathways. This strategy is synergistic with genomic and proteomic approaches and has yielded insights into the specialized nature of the target tissue microenvironment. However, for this vision to be realized, one must look, as recent literature suggests, beyond receptor levels and critically analyze ligand accessibility as a key determinant in pharmacodelivery systems.
Original language | English (US) |
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Pages (from-to) | 126-133 |
Number of pages | 8 |
Journal | Trends in Cardiovascular Medicine |
Volume | 18 |
Issue number | 4 |
DOIs | |
State | Published - May 2008 |
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
MD Anderson CCSG core facilities
- Advanced Technology Genomics Core