Beyond the symptom: the biology of fatigue

David M. Raizen; Janet Mullington; Christelle Anaclet; Gerard Clarke; Hugo Critchley; Robert Dantzer; Ronald Davis; Kelly L. Drew; Josh Fessel; Patrick M. Fuller; Erin M. Gibson; Mary Harrington; W. Ian Lipkin; Elizabeth B. Klerman; Nancy Klimas; Anthony L. Komaroff; Walter Koroshetz; Lauren Krupp; Anna Kuppuswamy; Julie Lasselin; Laura D. Lewis; Pierre J. Magistretti; Heidi Y. Matos; Christine Miaskowski; Andrew H. Miller; Avindra Nath; Maiken Nedergaard; Mark R. Opp; Marylyn D. Ritchie; Dragana Rogulja; Asya Rolls; John D. Salamone; Clifford Saper; Vicky Whittemore; Glenn Wylie; Jarred Younger; Phyllis C. Zee; H. Craig Heller

doi:10.1093/sleep/zsad069

Beyond the symptom: the biology of fatigue

David M. Raizen, Janet Mullington, Christelle Anaclet, Gerard Clarke, Hugo Critchley, Robert Dantzer, Ronald Davis, Kelly L. Drew, Josh Fessel, Patrick M. Fuller, Erin M. Gibson, Mary Harrington, W. Ian Lipkin, Elizabeth B. Klerman, Nancy Klimas, Anthony L. Komaroff, Walter Koroshetz, Lauren Krupp, Anna Kuppuswamy, Julie LasselinLaura D. Lewis, Pierre J. Magistretti, Heidi Y. Matos, Christine Miaskowski, Andrew H. Miller, Avindra Nath, Maiken Nedergaard, Mark R. Opp, Marylyn D. Ritchie, Dragana Rogulja, Asya Rolls, John D. Salamone, Clifford Saper, Vicky Whittemore, Glenn Wylie, Jarred Younger, Phyllis C. Zee, H. Craig Heller

Symptom Research CAO

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

A workshop titled “Beyond the Symptom: The Biology of Fatigue” was held virtually September 27–28, 2021. It was jointly organized by the Sleep Research Society and the Neurobiology of Fatigue Working Group of the NIH Blueprint Neuroscience Research Program. For access to the presentations and video recordings, see: https://neuroscienceblueprint.nih.gov/about/event/beyond-symptom-biology-fatigue. The goals of this workshop were to bring together clinicians and scientists who use a variety of research approaches to understand fatigue in multiple conditions and to identify key gaps in our understanding of the biology of fatigue. This workshop summary distills key issues discussed in this workshop and provides a list of promising directions for future research on this topic. We do not attempt to provide a comprehensive review of the state of our understanding of fatigue, nor to provide a comprehensive reprise of the many excellent presentations. Rather, our goal is to highlight key advances and to focus on questions and future approaches to answering them.

Original language	English (US)
Journal	Sleep
Volume	46
Issue number	9
DOIs	https://doi.org/10.1093/sleep/zsad069
State	Published - Sep 1 2023

ASJC Scopus subject areas

General Medicine

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10.1093/sleep/zsad069

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Raizen, D. M., Mullington, J., Anaclet, C., Clarke, G., Critchley, H., Dantzer, R., Davis, R., Drew, K. L., Fessel, J., Fuller, P. M., Gibson, E. M., Harrington, M., Lipkin, W. I., Klerman, E. B., Klimas, N., Komaroff, A. L., Koroshetz, W., Krupp, L., Kuppuswamy, A., ... Heller, H. C. (2023). Beyond the symptom: the biology of fatigue. Sleep, 46(9). https://doi.org/10.1093/sleep/zsad069

Raizen, DM, Mullington, J, Anaclet, C, Clarke, G, Critchley, H, Dantzer, R, Davis, R, Drew, KL, Fessel, J, Fuller, PM, Gibson, EM, Harrington, M, Lipkin, WI, Klerman, EB, Klimas, N, Komaroff, AL, Koroshetz, W, Krupp, L, Kuppuswamy, A, Lasselin, J, Lewis, LD, Magistretti, PJ, Matos, HY, Miaskowski, C, Miller, AH, Nath, A, Nedergaard, M, Opp, MR, Ritchie, MD, Rogulja, D, Rolls, A, Salamone, JD, Saper, C, Whittemore, V, Wylie, G, Younger, J, Zee, PC & Heller, HC 2023, 'Beyond the symptom: the biology of fatigue', Sleep, vol. 46, no. 9. https://doi.org/10.1093/sleep/zsad069

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title = "Beyond the symptom: the biology of fatigue",

abstract = "A workshop titled “Beyond the Symptom: The Biology of Fatigue” was held virtually September 27–28, 2021. It was jointly organized by the Sleep Research Society and the Neurobiology of Fatigue Working Group of the NIH Blueprint Neuroscience Research Program. For access to the presentations and video recordings, see: https://neuroscienceblueprint.nih.gov/about/event/beyond-symptom-biology-fatigue. The goals of this workshop were to bring together clinicians and scientists who use a variety of research approaches to understand fatigue in multiple conditions and to identify key gaps in our understanding of the biology of fatigue. This workshop summary distills key issues discussed in this workshop and provides a list of promising directions for future research on this topic. We do not attempt to provide a comprehensive review of the state of our understanding of fatigue, nor to provide a comprehensive reprise of the many excellent presentations. Rather, our goal is to highlight key advances and to focus on questions and future approaches to answering them.",

author = "Raizen, {David M.} and Janet Mullington and Christelle Anaclet and Gerard Clarke and Hugo Critchley and Robert Dantzer and Ronald Davis and Drew, {Kelly L.} and Josh Fessel and Fuller, {Patrick M.} and Gibson, {Erin M.} and Mary Harrington and Lipkin, {W. Ian} and Klerman, {Elizabeth B.} and Nancy Klimas and Komaroff, {Anthony L.} and Walter Koroshetz and Lauren Krupp and Anna Kuppuswamy and Julie Lasselin and Lewis, {Laura D.} and Magistretti, {Pierre J.} and Matos, {Heidi Y.} and Christine Miaskowski and Miller, {Andrew H.} and Avindra Nath and Maiken Nedergaard and Opp, {Mark R.} and Ritchie, {Marylyn D.} and Dragana Rogulja and Asya Rolls and Salamone, {John D.} and Clifford Saper and Vicky Whittemore and Glenn Wylie and Jarred Younger and Zee, {Phyllis C.} and Heller, {H. Craig}",

year = "2023",

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doi = "10.1093/sleep/zsad069",

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AU - Raizen, David M.

AU - Mullington, Janet

AU - Anaclet, Christelle

AU - Clarke, Gerard

AU - Critchley, Hugo

AU - Dantzer, Robert

AU - Davis, Ronald

AU - Drew, Kelly L.

AU - Fessel, Josh

AU - Fuller, Patrick M.

AU - Gibson, Erin M.

AU - Harrington, Mary

AU - Lipkin, W. Ian

AU - Klerman, Elizabeth B.

AU - Klimas, Nancy

AU - Komaroff, Anthony L.

AU - Koroshetz, Walter

AU - Krupp, Lauren

AU - Kuppuswamy, Anna

AU - Lasselin, Julie

AU - Lewis, Laura D.

AU - Magistretti, Pierre J.

AU - Matos, Heidi Y.

AU - Miaskowski, Christine

AU - Miller, Andrew H.

AU - Nath, Avindra

AU - Nedergaard, Maiken

AU - Opp, Mark R.

AU - Ritchie, Marylyn D.

AU - Rogulja, Dragana

AU - Rolls, Asya

AU - Salamone, John D.

AU - Saper, Clifford

AU - Whittemore, Vicky

AU - Wylie, Glenn

AU - Younger, Jarred

AU - Zee, Phyllis C.

AU - Heller, H. Craig

PY - 2023/9/1

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Beyond the symptom: the biology of fatigue

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