TY - JOUR
T1 - Bifunctional Gold Nanoshells with a Superparamagnetic Iron Oxide-Silica Core Suitable for Both MR Imaging and Photothermal Therapy
AU - Ji, Xiaojun
AU - Shao, Ruping
AU - Elliott, Andrew M.
AU - Jason Stafford, R.
AU - Esparza-Coss, Emilio
AU - Bankson, James A.
AU - Liang, Gan
AU - Luo, Zhi Ping
AU - Park, Keeseong
AU - Markert, John T.
AU - Li, Chun
PY - 2007/5/3
Y1 - 2007/5/3
N2 - We describe the synthesis, characterization, and use of hybrid nanoparticles with a superparamagnetic iron oxide (SPIO)-silica core and a gold nanoshell. These multifunctional nanoparticles, designated SPIO-Au nanoshells, displayed superparamagnetic characteristics and a significant absorbance in the near-infrared (NIR) region of the electromagnetic spectrum. In addition, they exhibited high transverse relaxivities, R2, and a large R 2/R1 ratio, and therefore, they could be imaged by MRI to obtain T2-weighted images. Moreover, the SPIO-Au nanoshells showed efficient photothermal effects when exposed to NIR light. The use of SPIO-Au nanoshells, with their combination of unique magnetic and optical properties, should enhance the efficacy of nanoshell-mediated photothermal therapy by making it possible to direct more nanoparticles to tumors through the application of external magnetic field and by permitting real-time in vivo MRI imaging of the distribution of the nanoparticles before, during, and after photothermal therapy.
AB - We describe the synthesis, characterization, and use of hybrid nanoparticles with a superparamagnetic iron oxide (SPIO)-silica core and a gold nanoshell. These multifunctional nanoparticles, designated SPIO-Au nanoshells, displayed superparamagnetic characteristics and a significant absorbance in the near-infrared (NIR) region of the electromagnetic spectrum. In addition, they exhibited high transverse relaxivities, R2, and a large R 2/R1 ratio, and therefore, they could be imaged by MRI to obtain T2-weighted images. Moreover, the SPIO-Au nanoshells showed efficient photothermal effects when exposed to NIR light. The use of SPIO-Au nanoshells, with their combination of unique magnetic and optical properties, should enhance the efficacy of nanoshell-mediated photothermal therapy by making it possible to direct more nanoparticles to tumors through the application of external magnetic field and by permitting real-time in vivo MRI imaging of the distribution of the nanoparticles before, during, and after photothermal therapy.
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U2 - 10.1021/jp0702245
DO - 10.1021/jp0702245
M3 - Article
C2 - 20165552
AN - SCOPUS:34249003488
SN - 1932-7447
VL - 111
SP - 6245
EP - 6251
JO - Journal of Physical Chemistry C
JF - Journal of Physical Chemistry C
IS - 17
ER -