TY - JOUR
T1 - Bile acid malabsorption associated with graves’ disease
AU - Subba Raju, Gottumukkala
AU - Dawson, Barbara
AU - Bardhan, Kama Dev
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1994/7
Y1 - 1994/7
N2 - A 40–year–old man developed dyspepsia, watery diarrhea, and weight loss. A clinical diagnosis of hyperthyroidism due to Graves’ disease was confirmed [free thyroxine, 87 pmol/L (normal range, 8.6–27 pmol/L)]. Bile acid malabsorption was demonstrated by a low 23– selena–25–homocholyltauric acid retention of 7.1% (normal, >15%). Antithyroid treatment (carbimazole and propranolol) was instituted, and his diarrhea subsided with the control of hyperthyroidism (free thyroxine, 15 pmol/L) along with an improvement of bile acid absorption (Se–HCAT retention, 14.7%). This case very strongly suggests the existence of bile acid malabsorption in hyperthyroidism. The temporal association suggests that the diarrhea may have been due at least in part to bile acid malabsorption, raising the possibility that the latter may be an etiological factor in thyrotoxic diarrhea. We believe this is the first such report.
AB - A 40–year–old man developed dyspepsia, watery diarrhea, and weight loss. A clinical diagnosis of hyperthyroidism due to Graves’ disease was confirmed [free thyroxine, 87 pmol/L (normal range, 8.6–27 pmol/L)]. Bile acid malabsorption was demonstrated by a low 23– selena–25–homocholyltauric acid retention of 7.1% (normal, >15%). Antithyroid treatment (carbimazole and propranolol) was instituted, and his diarrhea subsided with the control of hyperthyroidism (free thyroxine, 15 pmol/L) along with an improvement of bile acid absorption (Se–HCAT retention, 14.7%). This case very strongly suggests the existence of bile acid malabsorption in hyperthyroidism. The temporal association suggests that the diarrhea may have been due at least in part to bile acid malabsorption, raising the possibility that the latter may be an etiological factor in thyrotoxic diarrhea. We believe this is the first such report.
KW - Diarrhea
KW - Graves’ disease
KW - Idiopathic bile acid malabsorption
KW - Se-HCAT test
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U2 - 10.1097/00004836-199407000-00014
DO - 10.1097/00004836-199407000-00014
M3 - Article
C2 - 7930435
AN - SCOPUS:0028272106
SN - 0192-0790
VL - 19
SP - 54
EP - 56
JO - Journal of Clinical Gastroenterology
JF - Journal of Clinical Gastroenterology
IS - 1
ER -