Biliary tract cancer

John A. Ehrenfried; Jean Nicolas Vauthey

doi:10.1097/00001574-199909000-00010

Biliary tract cancer

John A. Ehrenfried, Jean Nicolas Vauthey

Surgical Oncology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Recent advances in the molecular and cellular biology, diagnosis, and treatment of biliary tract cancer are reviewed. Several studies have delineated the molecular and cellular biology of cholangiocarcinoma and gallbladder carcinoma. Hepatocyte growth factor seems to be mitogenic to gallbladder carcinoma, and its inhibition may have a therapeutic role in this disease. Evidence against an adenoma-carcinoma pathway in gallbladder mucosa is presented. Helical computed tomography may improve staging accuracy in biliary tract disease and plays a definite role in diagnosis of and treatment planning in gallbladder polyps. Complete surgical resection continues to provide the best long-term prognosis, and surgical drainage is most beneficial in cholangiocarcinoma. Controversy continues about the effects of laparoscopic procedures and abdominal wall tumor recurrence.

Original language	English (US)
Pages (from-to)	430-435
Number of pages	6
Journal	Current opinion in gastroenterology
Volume	15
Issue number	5
DOIs	https://doi.org/10.1097/00001574-199909000-00010
State	Published - 1999

ASJC Scopus subject areas

Gastroenterology

Access to Document

10.1097/00001574-199909000-00010

Cite this

@article{68c9e18848054e4789faf712330ab361,

title = "Biliary tract cancer",

abstract = "Recent advances in the molecular and cellular biology, diagnosis, and treatment of biliary tract cancer are reviewed. Several studies have delineated the molecular and cellular biology of cholangiocarcinoma and gallbladder carcinoma. Hepatocyte growth factor seems to be mitogenic to gallbladder carcinoma, and its inhibition may have a therapeutic role in this disease. Evidence against an adenoma-carcinoma pathway in gallbladder mucosa is presented. Helical computed tomography may improve staging accuracy in biliary tract disease and plays a definite role in diagnosis of and treatment planning in gallbladder polyps. Complete surgical resection continues to provide the best long-term prognosis, and surgical drainage is most beneficial in cholangiocarcinoma. Controversy continues about the effects of laparoscopic procedures and abdominal wall tumor recurrence.",

author = "Ehrenfried, {John A.} and Vauthey, {Jean Nicolas}",

year = "1999",

doi = "10.1097/00001574-199909000-00010",

language = "English (US)",

volume = "15",

pages = "430--435",

journal = "Current opinion in gastroenterology",

issn = "0267-1379",

publisher = "Lippincott Williams and Wilkins",

number = "5",

}

TY - JOUR

T1 - Biliary tract cancer

AU - Ehrenfried, John A.

AU - Vauthey, Jean Nicolas

PY - 1999

Y1 - 1999

N2 - Recent advances in the molecular and cellular biology, diagnosis, and treatment of biliary tract cancer are reviewed. Several studies have delineated the molecular and cellular biology of cholangiocarcinoma and gallbladder carcinoma. Hepatocyte growth factor seems to be mitogenic to gallbladder carcinoma, and its inhibition may have a therapeutic role in this disease. Evidence against an adenoma-carcinoma pathway in gallbladder mucosa is presented. Helical computed tomography may improve staging accuracy in biliary tract disease and plays a definite role in diagnosis of and treatment planning in gallbladder polyps. Complete surgical resection continues to provide the best long-term prognosis, and surgical drainage is most beneficial in cholangiocarcinoma. Controversy continues about the effects of laparoscopic procedures and abdominal wall tumor recurrence.

AB - Recent advances in the molecular and cellular biology, diagnosis, and treatment of biliary tract cancer are reviewed. Several studies have delineated the molecular and cellular biology of cholangiocarcinoma and gallbladder carcinoma. Hepatocyte growth factor seems to be mitogenic to gallbladder carcinoma, and its inhibition may have a therapeutic role in this disease. Evidence against an adenoma-carcinoma pathway in gallbladder mucosa is presented. Helical computed tomography may improve staging accuracy in biliary tract disease and plays a definite role in diagnosis of and treatment planning in gallbladder polyps. Complete surgical resection continues to provide the best long-term prognosis, and surgical drainage is most beneficial in cholangiocarcinoma. Controversy continues about the effects of laparoscopic procedures and abdominal wall tumor recurrence.

UR - http://www.scopus.com/inward/record.url?scp=0032814015&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032814015&partnerID=8YFLogxK

U2 - 10.1097/00001574-199909000-00010

DO - 10.1097/00001574-199909000-00010

M3 - Article

C2 - 17023985

AN - SCOPUS:0032814015

SN - 0267-1379

VL - 15

SP - 430

EP - 435

JO - Current opinion in gastroenterology

JF - Current opinion in gastroenterology

IS - 5

ER -

Biliary tract cancer

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this