Bio-interfacial magnetic resonance imaging of hyperpolarized contrast agents for metabolic flux interrogation in vivo

Gijin Jeong, Jee Wook Lee, Gyeonghyeon Gong, Hyeji Ko, Ikjang Choi, Hyeonglim Seo, Youngbok Lee, Niki M.Zacharias Millward, Pratip K. Bhattacharya

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We utilized dynamic nuclear polarization to hyperpolarize three metabolic imaging agents as single agents and together (co-polarization with two different organic radicals; OX63 and BDPA). In addition, we describe our initial two slice selective spectroscopy in vivo experiments in mice. These techniques along with advances by other laboratories will allow for multiple metabolic pathways to be imaged in real-time and in vivo.

Original languageEnglish (US)
Pages (from-to)224-228
Number of pages5
JournalJournal of Industrial and Engineering Chemistry
Volume36
DOIs
StatePublished - Apr 25 2016

Keywords

  • Dynamic nuclear polarization
  • Hyperpolarization
  • In vivo metabolic MR
  • MR spectroscopy and imaging

ASJC Scopus subject areas

  • General Chemical Engineering

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