TY - JOUR
T1 - Biologic characteristics and treatment of acute nonlymphocytic leukemia in children
AU - Lampkin, B. C.
AU - Lange, B.
AU - Bernstein, I.
AU - Woods, W.
AU - Odom, L.
AU - Wells, R.
AU - Ruymann, F.
AU - Feig, S.
AU - Miller, L.
AU - Chard, R.
AU - Benjamin, D.
AU - Buckley, J.
AU - Kim, T.
AU - Hammond, D.
N1 - Funding Information:
*Contributing Childrens Cancer Study Group Investigators (Institution and Grant Numbers are given in Appendix). Grant Support from Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Washington, D.C.
PY - 1988
Y1 - 1988
N2 - Major advances in the treatment of children with ANLL have occurred during the past 15 years. Today, approximately 75 per cent of patients will enter a complete remission, and about 40 per cent will have an event-free survival for over 3 years irrespective of whether they received a bone marrow transplant or chemotherapy after induction. A number of biologic characteristics of ANLL cells have been defined, but only three are clearly recognized in children today to have an impact on prognosis. These are a WBC greater than 100,000, monoblastic leukemia in infants less than 2 years of age, and certain chromosomal abnormalities.
AB - Major advances in the treatment of children with ANLL have occurred during the past 15 years. Today, approximately 75 per cent of patients will enter a complete remission, and about 40 per cent will have an event-free survival for over 3 years irrespective of whether they received a bone marrow transplant or chemotherapy after induction. A number of biologic characteristics of ANLL cells have been defined, but only three are clearly recognized in children today to have an impact on prognosis. These are a WBC greater than 100,000, monoblastic leukemia in infants less than 2 years of age, and certain chromosomal abnormalities.
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U2 - 10.1016/S0031-3955(16)36508-7
DO - 10.1016/S0031-3955(16)36508-7
M3 - Article
C2 - 3047652
AN - SCOPUS:0023769729
SN - 0031-3955
VL - 35
SP - 743
EP - 764
JO - Pediatric Clinics of North America
JF - Pediatric Clinics of North America
IS - 4
ER -