TY - JOUR
T1 - Biology and Management of Salivary Gland Cancers
AU - Adelstein, David J.
AU - Koyfman, Shlomo A.
AU - El-Naggar, Adel K.
AU - Hanna, Ehab Y.
PY - 2012/7
Y1 - 2012/7
N2 - The salivary gland cancers are uncommon neoplasms of the head and neck, which exhibit considerable pathologic, biological, and clinical diversity. Surgical resection, often with postoperative radiation, is the standard therapeutic approach, and the results after treatment vary widely depending on the tumor histology. Chemotherapy has been of only limited palliative benefit in patients with advanced disease, and there has been little exploration of its use in definitive management. Recent investigation has focused on identification of the characteristic molecular signatures and genomic alterations of the specific histologic subtypes. These efforts have suggested the potential for molecularly targeted therapies, and clinical trials exploring this approach are currently underway.
AB - The salivary gland cancers are uncommon neoplasms of the head and neck, which exhibit considerable pathologic, biological, and clinical diversity. Surgical resection, often with postoperative radiation, is the standard therapeutic approach, and the results after treatment vary widely depending on the tumor histology. Chemotherapy has been of only limited palliative benefit in patients with advanced disease, and there has been little exploration of its use in definitive management. Recent investigation has focused on identification of the characteristic molecular signatures and genomic alterations of the specific histologic subtypes. These efforts have suggested the potential for molecularly targeted therapies, and clinical trials exploring this approach are currently underway.
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U2 - 10.1016/j.semradonc.2012.03.009
DO - 10.1016/j.semradonc.2012.03.009
M3 - Review article
C2 - 22687949
AN - SCOPUS:84862146283
SN - 1053-4296
VL - 22
SP - 245
EP - 253
JO - Seminars in radiation oncology
JF - Seminars in radiation oncology
IS - 3
ER -