TY - JOUR
T1 - Biomarkers as surrogates for cancer development.
AU - Hawk, E.
AU - Viner, J. L.
AU - Lawrence, J. A.
PY - 2000/5
Y1 - 2000/5
N2 - Biomarkers are routinely applied in the management of chronic diseases to reduce morbidity and mortality through early diagnosis, as well as to assess the necessity for, and responsiveness to, applied interventions. Biomarkers yield mechanistic insights into layers of biologic organization from molecule to organelle, to cell, and finally to cellular organization and tissue. A step-wise approach to the development of tissue-based biomarkers is presented. These biomarkers may serve as molecular targets for scientific inquiry and intervention, as well as approvable endpoints for clinical trials.
AB - Biomarkers are routinely applied in the management of chronic diseases to reduce morbidity and mortality through early diagnosis, as well as to assess the necessity for, and responsiveness to, applied interventions. Biomarkers yield mechanistic insights into layers of biologic organization from molecule to organelle, to cell, and finally to cellular organization and tissue. A step-wise approach to the development of tissue-based biomarkers is presented. These biomarkers may serve as molecular targets for scientific inquiry and intervention, as well as approvable endpoints for clinical trials.
UR - http://www.scopus.com/inward/record.url?scp=0034188290&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034188290&partnerID=8YFLogxK
U2 - 10.1007/s11912-000-0074-0
DO - 10.1007/s11912-000-0074-0
M3 - Review article
C2 - 11122849
AN - SCOPUS:0034188290
SN - 1523-3790
VL - 2
SP - 242
EP - 250
JO - Current oncology reports
JF - Current oncology reports
IS - 3
ER -