TY - JOUR
T1 - Biphasic expression of lipin suggests dual roles in adipocyte development
AU - Phan, Jack
AU - Péterfy, Miklós
AU - Reue, Karen
PY - 2005/1
Y1 - 2005/1
N2 - The identification of gene mutations that cause lipodystrophies, conditions characterized by a lack of normal adipose tissue, has revealed new proteins that play a role in adipocyte biology. Lipin is one such protein identified in a lipodystrophic mouse strain and found to be critical for normal adipocyte differentiation. Interestingly, lipin displays a biphasic expression pattern in adipocytes, with peaks of expression at two points during adipogenesis-a transient induction in preadipocytes prior to expression of peroxisome proliferator-activated receptor γ, and a second wave of expression in mature adipocytes. Thus, lipin appears to have critical roles in both adipocyte differentiation and in the function of mature adipocytes.
AB - The identification of gene mutations that cause lipodystrophies, conditions characterized by a lack of normal adipose tissue, has revealed new proteins that play a role in adipocyte biology. Lipin is one such protein identified in a lipodystrophic mouse strain and found to be critical for normal adipocyte differentiation. Interestingly, lipin displays a biphasic expression pattern in adipocytes, with peaks of expression at two points during adipogenesis-a transient induction in preadipocytes prior to expression of peroxisome proliferator-activated receptor γ, and a second wave of expression in mature adipocytes. Thus, lipin appears to have critical roles in both adipocyte differentiation and in the function of mature adipocytes.
UR - http://www.scopus.com/inward/record.url?scp=17444422470&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17444422470&partnerID=8YFLogxK
U2 - 10.1358/dnp.2005.18.1.877164
DO - 10.1358/dnp.2005.18.1.877164
M3 - Review article
C2 - 15753971
AN - SCOPUS:17444422470
SN - 0214-0934
VL - 18
SP - 5
EP - 11
JO - Drug News and Perspectives
JF - Drug News and Perspectives
IS - 1
ER -