Abstract
The term biphasic is most commonly applied to tumors with malignant mesenchymal (sarcomatous) and epithelial (carcinomatous) components but in the wider sense is also used for tumors with epithelial-epithelial differentiation (pleomorphic carcinoma), epithelial-myoepithelial differentiation (salivary gland-type tumors), mesenchymal-mesenchymal differentiation (malignant triton tumor), and tumors of unidirectional differentiation but with mixed sarcomatoid and epithelioid cell morphology (biphasic synovial sarcoma, biphasic malignant mesothelioma). Use of the term “biphasic” in this chapter will be limited to those tumors with epithelial and mesenchymal components. Overall, such tumors are rare in the bronchopulmonary system, representing less than 2% of all primary lung tumors. In the adult population, this group of tumors includes carcinosarcoma and pulmonary blastoma. Recently, changes in the nomenclature have generated confusion as to their specific categorization. In addition, their putative histogenesis is still controversial and unsettled.
| Original language | English (US) |
|---|---|
| Title of host publication | Diagnostic Thoracic Pathology |
| Publisher | Springer International Publishing |
| Pages | 565-584 |
| Number of pages | 20 |
| ISBN (Electronic) | 9783030364380 |
| ISBN (Print) | 9783030364373 |
| DOIs | |
| State | Published - Jan 1 2020 |
Keywords
- Pleuropulmonary blastoma
- Pulmonary blastoma
- Pulmonary carcinosarcoma
ASJC Scopus subject areas
- General Medicine