TY - JOUR
T1 - Bismuth Nanoparticle and Polyhydroxybutyrate Coatings Enhance the Radiopacity of Absorbable Inferior Vena Cava Filters for Fluoroscopy-Guided Placement and Longitudinal Computed Tomography Monitoring in Pigs
AU - Damasco, Jossana A.
AU - Huang, Steven Y.
AU - Perez, Joy Vanessa D.
AU - Manongdo, John Andrew T.
AU - Dixon, Katherine A.
AU - Williams, Malea L.
AU - Jacobsen, Megan C.
AU - Barbosa, Roland
AU - Canlas, Gino Martin
AU - Chintalapani, Gouthami
AU - Melancon, Adam D.
AU - Layman, Rick R.
AU - Fowlkes, Natalie W.
AU - Whitley, Elizabeth M.
AU - Melancon, Marites P.
N1 - Funding Information:
This work was supported in part by grants from the National Institutes of Health─National Heart, Lung, and Blood Institute (1R01HL141831-01; to M.P.M.), MD Anderson’s Animal Facility and Small Animal Imaging Facility supported by the NIH through MD Anderson’s Cancer Center Support grant (CA016672), and the Dunn Foundation. The authors would like to thank Adient Medical, headed by Mitch Eggers and supported by Steven Dria, who kindly provided the uncoated PPDO IVCFs. SEM was done under the supervision of Dr. James Gu in the Electron Microscopy Core, while ICP-OES was done by Drs. Karem A. Court and Biana Godin in the Department of Nanomedicine at Houston Methodist Hospital; TEM was performed by Kenneth Dunner at the Electron Microscopy Core at MD Anderson, and ICP-MS was performed by Djene Keita under the supervision of Dr. Liang Dong of the Department of Pharmaceutics at Texas Southern University. We are also grateful for the support of the large animal veterinary staff headed by Drs. William Norton and Lori Hill. Lastly, we would like to acknowledge Joe Munch in MD Anderson’s Research Medical Library for editing the manuscript.
Publisher Copyright:
© 2022 American Chemical Society. All rights reserved.
PY - 2022/4/11
Y1 - 2022/4/11
N2 - Inferior vena cava filters (IVCFs) constructed with poly-p-dioxanone (PPDO) are promising alternatives to metallic filters and their associated risks and complications. Incorporating high-Z nanoparticles (NPs) improves PPDO IVCFs' radiopacity without adversely affecting their safety or performance. However, increased radiopacity from these studies are insufficient for filter visualization during fluoroscopy-guided PPDO IVCF deployment. This study focuses on the use of bismuth nanoparticles (BiNPs) as radiopacifiers to render sufficient signal intensity for the fluoroscopy-guided deployment and long-term CT monitoring of PPDO IVCFs. The use of polyhydroxybutyate (PHB) as an additional layer to increase the surface adsorption of NPs resulted in a 2-fold increase in BiNP coating (BiNP-PPDO IVCFs, 3.8%; BiNP-PPDO + PHB IVCFs, 6.2%), enabling complete filter visualization during fluoroscopy-guided IVCF deployment and, 1 week later, clot deployment. The biocompatibility, clot-trapping efficacy, and mechanical strength of the control PPDO (load-at-break, 6.23 ± 0.13 kg), BiNP-PPDO (6.10 ± 0.09 kg), and BiNP-PPDO + PHB (6.15 ± 0.13 kg) IVCFs did not differ significantly over a 12-week monitoring period in pigs. These results indicate that BiNP-PPDO + PHB can increase the radiodensity of a novel absorbable IVCF without compromising device strength. Visualizing the device under conventional radiographic imaging is key to allow safe and effective clinical translation of the device.
AB - Inferior vena cava filters (IVCFs) constructed with poly-p-dioxanone (PPDO) are promising alternatives to metallic filters and their associated risks and complications. Incorporating high-Z nanoparticles (NPs) improves PPDO IVCFs' radiopacity without adversely affecting their safety or performance. However, increased radiopacity from these studies are insufficient for filter visualization during fluoroscopy-guided PPDO IVCF deployment. This study focuses on the use of bismuth nanoparticles (BiNPs) as radiopacifiers to render sufficient signal intensity for the fluoroscopy-guided deployment and long-term CT monitoring of PPDO IVCFs. The use of polyhydroxybutyate (PHB) as an additional layer to increase the surface adsorption of NPs resulted in a 2-fold increase in BiNP coating (BiNP-PPDO IVCFs, 3.8%; BiNP-PPDO + PHB IVCFs, 6.2%), enabling complete filter visualization during fluoroscopy-guided IVCF deployment and, 1 week later, clot deployment. The biocompatibility, clot-trapping efficacy, and mechanical strength of the control PPDO (load-at-break, 6.23 ± 0.13 kg), BiNP-PPDO (6.10 ± 0.09 kg), and BiNP-PPDO + PHB (6.15 ± 0.13 kg) IVCFs did not differ significantly over a 12-week monitoring period in pigs. These results indicate that BiNP-PPDO + PHB can increase the radiodensity of a novel absorbable IVCF without compromising device strength. Visualizing the device under conventional radiographic imaging is key to allow safe and effective clinical translation of the device.
KW - bismuth
KW - medical device
KW - radiopacity
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UR - http://www.scopus.com/inward/citedby.url?scp=85127938497&partnerID=8YFLogxK
U2 - 10.1021/acsbiomaterials.1c01449
DO - 10.1021/acsbiomaterials.1c01449
M3 - Article
C2 - 35343679
AN - SCOPUS:85127938497
SN - 2373-9878
VL - 8
SP - 1676
EP - 1685
JO - ACS Biomaterial Science and Engineering
JF - ACS Biomaterial Science and Engineering
IS - 4
ER -