Bis(s-acyl-2-thioethyl)esters of 2’3’-dideoxy adenosine 5’-monophosphate are potent anti-hiv agents in cell culture

C. Périgaud; G. Gosselin; S. Benzaria; J. L. Girardet; G. Maury; H. Pélicano; J. L. Imbach

doi:10.1080/15257779508012472

Bis(s-acyl-2-thioethyl)esters of 2’3’-dideoxy adenosine 5’-monophosphate are potent anti-hiv agents in cell culture

C. Périgaud, G. Gosselin, S. Benzaria, J. L. Girardet, G. Maury, H. Pélicano, J. L. Imbach

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

It is shown that ddA bis(SATE)phosphotriesters have potent anti-HIV activity in cell culture. Thus, compared with the parent nucleoside, a decrease of 3 or 4 orders of magnitude was observed in the EC50 values for the bis(S-acetyl-2-thioethyl)phosphotriester derivative, which makes this compound as active as AZT.

Original language	English (US)
Pages (from-to)	789-791
Number of pages	3
Journal	Nucleosides and Nucleotides
Volume	14
Issue number	3-5
DOIs	https://doi.org/10.1080/15257779508012472
State	Published - May 1 1995
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Genetics

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10.1080/15257779508012472

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title = "Bis(s-acyl-2-thioethyl)esters of 2{\textquoteright}3{\textquoteright}-dideoxy adenosine 5{\textquoteright}-monophosphate are potent anti-hiv agents in cell culture",

abstract = "It is shown that ddA bis(SATE)phosphotriesters have potent anti-HIV activity in cell culture. Thus, compared with the parent nucleoside, a decrease of 3 or 4 orders of magnitude was observed in the EC50 values for the bis(S-acetyl-2-thioethyl)phosphotriester derivative, which makes this compound as active as AZT.",

author = "C. P{\'e}rigaud and G. Gosselin and S. Benzaria and Girardet, {J. L.} and G. Maury and H. P{\'e}licano and Imbach, {J. L.}",

year = "1995",

month = may,

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doi = "10.1080/15257779508012472",

language = "English (US)",

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journal = "Nucleosides and Nucleotides",

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T1 - Bis(s-acyl-2-thioethyl)esters of 2’3’-dideoxy adenosine 5’-monophosphate are potent anti-hiv agents in cell culture

AU - Périgaud, C.

AU - Gosselin, G.

AU - Benzaria, S.

AU - Girardet, J. L.

AU - Maury, G.

AU - Pélicano, H.

AU - Imbach, J. L.

PY - 1995/5/1

Y1 - 1995/5/1

N2 - It is shown that ddA bis(SATE)phosphotriesters have potent anti-HIV activity in cell culture. Thus, compared with the parent nucleoside, a decrease of 3 or 4 orders of magnitude was observed in the EC50 values for the bis(S-acetyl-2-thioethyl)phosphotriester derivative, which makes this compound as active as AZT.

AB - It is shown that ddA bis(SATE)phosphotriesters have potent anti-HIV activity in cell culture. Thus, compared with the parent nucleoside, a decrease of 3 or 4 orders of magnitude was observed in the EC50 values for the bis(S-acetyl-2-thioethyl)phosphotriester derivative, which makes this compound as active as AZT.

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U2 - 10.1080/15257779508012472

DO - 10.1080/15257779508012472

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IS - 3-5

ER -

Bis(s-acyl-2-thioethyl)esters of 2’3’-dideoxy adenosine 5’-monophosphate are potent anti-hiv agents in cell culture

Abstract

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