Bladder cancer stem cells: Biological and therapeutic perspectives

G. Goodwin Jinesh; Daniel Levi Willis; Ashish M. Kamat

doi:10.2174/1574888x08666131113123051

Bladder cancer stem cells: Biological and therapeutic perspectives

G. Goodwin Jinesh, Daniel Levi Willis, Ashish M. Kamat

Urology

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Bladder cancer stem cell research is rapidly expanding based on the knowledge of cancer stem cells from various cancer types and normal stem cells as models. In various cancer types, cancer stem cells have been implicated in therapeutic resistance and relapse after initial therapy. Understanding how cancer stem cells differ from bulk cancer cells and how cancer stem cells contribute to relapse and resistance are essential to develop novel therapeutics to target cancer stem cells effectively. Here we review the latest information on bladder cancer stem cells, their biological characteristics, including their response to treatment, recurrence, immune context and technical problems encountered in bladder cancer stem cell research.

Original language	English (US)
Pages (from-to)	89-101
Number of pages	13
Journal	Current Stem Cell Research and Therapy
Volume	9
Issue number	2
DOIs	https://doi.org/10.2174/1574888x08666131113123051
State	Published - 2014

Keywords

Blebbishields
C-Met
CD44
Cancer stem cells
Neutrophils
T-cells
VEGFR2

ASJC Scopus subject areas

Medicine (miscellaneous)

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title = "Bladder cancer stem cells: Biological and therapeutic perspectives",

abstract = "Bladder cancer stem cell research is rapidly expanding based on the knowledge of cancer stem cells from various cancer types and normal stem cells as models. In various cancer types, cancer stem cells have been implicated in therapeutic resistance and relapse after initial therapy. Understanding how cancer stem cells differ from bulk cancer cells and how cancer stem cells contribute to relapse and resistance are essential to develop novel therapeutics to target cancer stem cells effectively. Here we review the latest information on bladder cancer stem cells, their biological characteristics, including their response to treatment, recurrence, immune context and technical problems encountered in bladder cancer stem cell research.",

keywords = "Blebbishields, C-Met, CD44, Cancer stem cells, Neutrophils, T-cells, VEGFR2",

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AU - Goodwin Jinesh, G.

AU - Willis, Daniel Levi

AU - Kamat, Ashish M.

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AB - Bladder cancer stem cell research is rapidly expanding based on the knowledge of cancer stem cells from various cancer types and normal stem cells as models. In various cancer types, cancer stem cells have been implicated in therapeutic resistance and relapse after initial therapy. Understanding how cancer stem cells differ from bulk cancer cells and how cancer stem cells contribute to relapse and resistance are essential to develop novel therapeutics to target cancer stem cells effectively. Here we review the latest information on bladder cancer stem cells, their biological characteristics, including their response to treatment, recurrence, immune context and technical problems encountered in bladder cancer stem cell research.

KW - Blebbishields

KW - C-Met

KW - CD44

KW - Cancer stem cells

KW - Neutrophils

KW - T-cells

KW - VEGFR2

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Bladder cancer stem cells: Biological and therapeutic perspectives

Abstract

Keywords

ASJC Scopus subject areas

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