TY - JOUR
T1 - Blastic crisis in chronic granulocytic leukemia
T2 - Experience in 39 patients
AU - Vallejos, Carlos S.
AU - Trujillo, José M.
AU - Cork, Ann
AU - Bodey, Gerald P.
AU - McCredie, Kenneth B.
AU - Freireich, Emil J.
PY - 1974/11
Y1 - 1974/11
N2 - In an attempt to prolong survival, a group of 39 adult patients with chronic granulocytic leukemia in acute transformation was treated with intensive chemotherapy regimens which included the use of single agents or drug combinations. An over‐all remission rate of 28% was obtained, with only 10% of the patients achieving complete remission. The cytogenetic profiles obtained during the acute phase of the disease were correlated with the clinical findings and the response to therapy. The results presented in this report indicate that, even with the use of modern therapeutic drugs, once chronic granulocytic leukemia enters a phase of acute transformation, the prognosis is equally poor for both Ph1 negative and Ph1 positive patients.
AB - In an attempt to prolong survival, a group of 39 adult patients with chronic granulocytic leukemia in acute transformation was treated with intensive chemotherapy regimens which included the use of single agents or drug combinations. An over‐all remission rate of 28% was obtained, with only 10% of the patients achieving complete remission. The cytogenetic profiles obtained during the acute phase of the disease were correlated with the clinical findings and the response to therapy. The results presented in this report indicate that, even with the use of modern therapeutic drugs, once chronic granulocytic leukemia enters a phase of acute transformation, the prognosis is equally poor for both Ph1 negative and Ph1 positive patients.
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U2 - 10.1002/1097-0142(197411)34:5<1806::AID-CNCR2820340531>3.0.CO;2-1
DO - 10.1002/1097-0142(197411)34:5<1806::AID-CNCR2820340531>3.0.CO;2-1
M3 - Article
C2 - 4529662
AN - SCOPUS:0016163267
SN - 0008-543X
VL - 34
SP - 1806
EP - 1812
JO - Cancer
JF - Cancer
IS - 5
ER -