Blockade of PDGFR-β2 activation eliminates morphine analgesic tolerance

Yan Wang; Katherine Barker; Shanping Shi; Miguel Diaz; Bing Mo; Howard B. Gutstein

doi:10.1038/nm.2633

Blockade of PDGFR-β2 activation eliminates morphine analgesic tolerance

Yan Wang, Katherine Barker, Shanping Shi, Miguel Diaz, Bing Mo, Howard B. Gutstein

Anesthesiology & PeriOperative Medicine

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

For centuries, opioid drugs have been the mainstay of chronic pain treatment. However, over time analgesic tolerance develops, leaving few treatment options. Here we show that platelet-derived growth factor receptor-β2 (PDGFR-β2)-mediated signaling plays a key role in morphine tolerance. PDGFR-β2 inhibition selectively eliminates morphine tolerance in rats. PDGFR-β2 inhibitors are widely used and well tolerated, suggesting that clinical translation of our findings could reduce the suffering endured by individuals with intractable pain.

Original language	English (US)
Pages (from-to)	385-387
Number of pages	3
Journal	Nature medicine
Volume	18
Issue number	3
DOIs	https://doi.org/10.1038/nm.2633
State	Published - Mar 2012

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1038/nm.2633

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Blockade of PDGFR-β2 activation eliminates morphine analgesic tolerance

Abstract

ASJC Scopus subject areas

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