Blood based biomarkers beyond genomics for lung cancer screening

Samir M. Hanash; Edwin Justin Ostrin; Johannes F. Fahrmann

doi:10.21037/tlcr.2018.05.13

Blood based biomarkers beyond genomics for lung cancer screening

Samir M. Hanash, Edwin Justin Ostrin, Johannes F. Fahrmann

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

While there is considerable interest at the present time in the development of so-called liquid biopsy approaches for cancer detection based notably on circulating tumor DNA, there are other types of potential biomarkers that show promise for lung cancer screening and early detection. Here we review approaches and some of the promising markers based on proteomics, metabolomics and the immune response to tumor antigens in the form of autoantibodies.

Original language	English (US)
Pages (from-to)	327-335
Number of pages	9
Journal	Translational Lung Cancer Research
Volume	7
Issue number	3
DOIs	https://doi.org/10.21037/tlcr.2018.05.13
State	Published - Jun 1 2018

Keywords

Autoantibodies
Biomarkers
Metabolites
Proteins

ASJC Scopus subject areas

Oncology

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10.21037/tlcr.2018.05.13

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title = "Blood based biomarkers beyond genomics for lung cancer screening",

abstract = "While there is considerable interest at the present time in the development of so-called liquid biopsy approaches for cancer detection based notably on circulating tumor DNA, there are other types of potential biomarkers that show promise for lung cancer screening and early detection. Here we review approaches and some of the promising markers based on proteomics, metabolomics and the immune response to tumor antigens in the form of autoantibodies.",

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AU - Ostrin, Edwin Justin

AU - Fahrmann, Johannes F.

N1 - Publisher Copyright: © Translational lung cancer research.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - While there is considerable interest at the present time in the development of so-called liquid biopsy approaches for cancer detection based notably on circulating tumor DNA, there are other types of potential biomarkers that show promise for lung cancer screening and early detection. Here we review approaches and some of the promising markers based on proteomics, metabolomics and the immune response to tumor antigens in the form of autoantibodies.

AB - While there is considerable interest at the present time in the development of so-called liquid biopsy approaches for cancer detection based notably on circulating tumor DNA, there are other types of potential biomarkers that show promise for lung cancer screening and early detection. Here we review approaches and some of the promising markers based on proteomics, metabolomics and the immune response to tumor antigens in the form of autoantibodies.

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KW - Biomarkers

KW - Metabolites

KW - Proteins

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Blood based biomarkers beyond genomics for lung cancer screening

Abstract

Keywords

ASJC Scopus subject areas

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