Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: Modeling odds ratios in pooled case-control data

Jay H. Lubin; Mia M. Gaudet; Andrew F. Olshan; Karl Kelsey; Paolo Boffetta; Paul Brennan; Xavier Castellsague; Chu Chen; Maria Paula Curado; Luigino Dal Maso; Alexander W. Daudt; Eleonora Fabianova; Leticia Fernandez; Victor Wünsch-Filho; Silvia Franceschi; Rolando Herrero; Sergio Koifman; Carlo La Vecchia; Philip Lazarus; Fabio Levi; Jolanta Lissowska; Ioan Nicolae Mates; Elena Matos; Michael McClean; Ana Menezes; Hal Morgenstern; Joshua Muscat; Jose Eluf Neto; Mark P. Purdue; Peter Rudnai; Stephen M. Schwartz; Oxana Shangina; Erich M. Sturgis; Neonilia Szeszenia-Dabrowska; Renato Talamini; Qingyi Wei; Deborah Winn; Zuo Feng Zhang; Mia Hashibe; Richard B. Hayes

doi:10.1093/aje/kwq088

Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: Modeling odds ratios in pooled case-control data

Jay H. Lubin, Mia M. Gaudet, Andrew F. Olshan, Karl Kelsey, Paolo Boffetta, Paul Brennan, Xavier Castellsague, Chu Chen, Maria Paula Curado, Luigino Dal Maso, Alexander W. Daudt, Eleonora Fabianova, Leticia Fernandez, Victor Wünsch-Filho, Silvia Franceschi, Rolando Herrero, Sergio Koifman, Carlo La Vecchia, Philip Lazarus, Fabio LeviJolanta Lissowska, Ioan Nicolae Mates, Elena Matos, Michael McClean, Ana Menezes, Hal Morgenstern, Joshua Muscat, Jose Eluf Neto, Mark P. Purdue, Peter Rudnai, Stephen M. Schwartz, Oxana Shangina, Erich M. Sturgis, Neonilia Szeszenia-Dabrowska, Renato Talamini, Qingyi Wei, Deborah Winn, Zuo Feng Zhang, Mia Hashibe, Richard B. Hayes

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Abstract

Odds ratios for head and neck cancer increase with greater cigarette and alcohol use and lower body mass index (BMI; weight (kg)/height² (m²)). Using data from the International Head and Neck Cancer Epidemiology Consortium, the authors conducted a formal analysis of BMI as a modifier of smoking-and alcohol-related effects. Analysis of never and current smokers included 6,333 cases, while analysis of never drinkers and consumers of ≤10 drinks/day included 8,452 cases. There were 8,000 or more controls, depending on the analysis. Odds ratios for all sites increased with lower BMI, greater smoking, and greater drinking. In polytomous regression, odds ratios for BMI (P = 0.65), smoking (P = 0.52), and drinking (P = 0.73) were homogeneous for oral cavity and pharyngeal cancers. Odds ratios for BMI and drinking were greater for oral cavity/pharyngeal cancer (P < 0.01), while smoking odds ratios were greater for laryngeal cancer (P < 0.01). Lower BMI enhanced smoking-and drinking-related odds ratios for oral cavity/pharyngeal cancer (P < 0.01), while BMI did not modify smoking and drinking odds ratios for laryngeal cancer.

Original language	English (US)
Pages (from-to)	1250-1261
Number of pages	12
Journal	American journal of epidemiology
Volume	171
Issue number	12
DOIs	https://doi.org/10.1093/aje/kwq088
State	Published - 2010

Keywords

Alcohol drinking
Body mass index
Laryngeal neoplasms
Models, statistical
Mouth neoplasms
Odds ratio
Pharyngeal neoplasms
Smoking

ASJC Scopus subject areas

Epidemiology

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Lubin, J. H., Gaudet, M. M., Olshan, A. F., Kelsey, K., Boffetta, P., Brennan, P., Castellsague, X., Chen, C., Curado, M. P., Maso, L. D., Daudt, A. W., Fabianova, E., Fernandez, L., Wünsch-Filho, V., Franceschi, S., Herrero, R., Koifman, S., La Vecchia, C., Lazarus, P., ... Hayes, R. B. (2010). Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: Modeling odds ratios in pooled case-control data. American journal of epidemiology, 171(12), 1250-1261. https://doi.org/10.1093/aje/kwq088

Lubin, JH, Gaudet, MM, Olshan, AF, Kelsey, K, Boffetta, P, Brennan, P, Castellsague, X, Chen, C, Curado, MP, Maso, LD, Daudt, AW, Fabianova, E, Fernandez, L, Wünsch-Filho, V, Franceschi, S, Herrero, R, Koifman, S, La Vecchia, C, Lazarus, P, Levi, F, Lissowska, J, Mates, IN, Matos, E, McClean, M, Menezes, A, Morgenstern, H, Muscat, J, Neto, JE, Purdue, MP, Rudnai, P, Schwartz, SM, Shangina, O, Sturgis, EM, Szeszenia-Dabrowska, N, Talamini, R, Wei, Q, Winn, D, Zhang, ZF, Hashibe, M & Hayes, RB 2010, 'Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: Modeling odds ratios in pooled case-control data', American journal of epidemiology, vol. 171, no. 12, pp. 1250-1261. https://doi.org/10.1093/aje/kwq088

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title = "Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: Modeling odds ratios in pooled case-control data",

abstract = "Odds ratios for head and neck cancer increase with greater cigarette and alcohol use and lower body mass index (BMI; weight (kg)/height2 (m2)). Using data from the International Head and Neck Cancer Epidemiology Consortium, the authors conducted a formal analysis of BMI as a modifier of smoking-and alcohol-related effects. Analysis of never and current smokers included 6,333 cases, while analysis of never drinkers and consumers of ≤10 drinks/day included 8,452 cases. There were 8,000 or more controls, depending on the analysis. Odds ratios for all sites increased with lower BMI, greater smoking, and greater drinking. In polytomous regression, odds ratios for BMI (P = 0.65), smoking (P = 0.52), and drinking (P = 0.73) were homogeneous for oral cavity and pharyngeal cancers. Odds ratios for BMI and drinking were greater for oral cavity/pharyngeal cancer (P < 0.01), while smoking odds ratios were greater for laryngeal cancer (P < 0.01). Lower BMI enhanced smoking-and drinking-related odds ratios for oral cavity/pharyngeal cancer (P < 0.01), while BMI did not modify smoking and drinking odds ratios for laryngeal cancer.",

keywords = "Alcohol drinking, Body mass index, Laryngeal neoplasms, Models, statistical, Mouth neoplasms, Odds ratio, Pharyngeal neoplasms, Smoking",

author = "Lubin, {Jay H.} and Gaudet, {Mia M.} and Olshan, {Andrew F.} and Karl Kelsey and Paolo Boffetta and Paul Brennan and Xavier Castellsague and Chu Chen and Curado, {Maria Paula} and Maso, {Luigino Dal} and Daudt, {Alexander W.} and Eleonora Fabianova and Leticia Fernandez and Victor W{\"u}nsch-Filho and Silvia Franceschi and Rolando Herrero and Sergio Koifman and {La Vecchia}, Carlo and Philip Lazarus and Fabio Levi and Jolanta Lissowska and Mates, {Ioan Nicolae} and Elena Matos and Michael McClean and Ana Menezes and Hal Morgenstern and Joshua Muscat and Neto, {Jose Eluf} and Purdue, {Mark P.} and Peter Rudnai and Schwartz, {Stephen M.} and Oxana Shangina and Sturgis, {Erich M.} and Neonilia Szeszenia-Dabrowska and Renato Talamini and Qingyi Wei and Deborah Winn and Zhang, {Zuo Feng} and Mia Hashibe and Hayes, {Richard B.}",

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doi = "10.1093/aje/kwq088",

language = "English (US)",

volume = "171",

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T1 - Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx

T2 - Modeling odds ratios in pooled case-control data

AU - Lubin, Jay H.

AU - Gaudet, Mia M.

AU - Olshan, Andrew F.

AU - Kelsey, Karl

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - Castellsague, Xavier

AU - Chen, Chu

AU - Curado, Maria Paula

AU - Maso, Luigino Dal

AU - Daudt, Alexander W.

AU - Fabianova, Eleonora

AU - Fernandez, Leticia

AU - Wünsch-Filho, Victor

AU - Franceschi, Silvia

AU - Herrero, Rolando

AU - Koifman, Sergio

AU - La Vecchia, Carlo

AU - Lazarus, Philip

AU - Levi, Fabio

AU - Lissowska, Jolanta

AU - Mates, Ioan Nicolae

AU - Matos, Elena

AU - McClean, Michael

AU - Menezes, Ana

AU - Morgenstern, Hal

AU - Muscat, Joshua

AU - Neto, Jose Eluf

AU - Purdue, Mark P.

AU - Rudnai, Peter

AU - Schwartz, Stephen M.

AU - Shangina, Oxana

AU - Sturgis, Erich M.

AU - Szeszenia-Dabrowska, Neonilia

AU - Talamini, Renato

AU - Wei, Qingyi

AU - Winn, Deborah

AU - Zhang, Zuo Feng

AU - Hashibe, Mia

AU - Hayes, Richard B.

PY - 2010

Y1 - 2010

N2 - Odds ratios for head and neck cancer increase with greater cigarette and alcohol use and lower body mass index (BMI; weight (kg)/height2 (m2)). Using data from the International Head and Neck Cancer Epidemiology Consortium, the authors conducted a formal analysis of BMI as a modifier of smoking-and alcohol-related effects. Analysis of never and current smokers included 6,333 cases, while analysis of never drinkers and consumers of ≤10 drinks/day included 8,452 cases. There were 8,000 or more controls, depending on the analysis. Odds ratios for all sites increased with lower BMI, greater smoking, and greater drinking. In polytomous regression, odds ratios for BMI (P = 0.65), smoking (P = 0.52), and drinking (P = 0.73) were homogeneous for oral cavity and pharyngeal cancers. Odds ratios for BMI and drinking were greater for oral cavity/pharyngeal cancer (P < 0.01), while smoking odds ratios were greater for laryngeal cancer (P < 0.01). Lower BMI enhanced smoking-and drinking-related odds ratios for oral cavity/pharyngeal cancer (P < 0.01), while BMI did not modify smoking and drinking odds ratios for laryngeal cancer.

AB - Odds ratios for head and neck cancer increase with greater cigarette and alcohol use and lower body mass index (BMI; weight (kg)/height2 (m2)). Using data from the International Head and Neck Cancer Epidemiology Consortium, the authors conducted a formal analysis of BMI as a modifier of smoking-and alcohol-related effects. Analysis of never and current smokers included 6,333 cases, while analysis of never drinkers and consumers of ≤10 drinks/day included 8,452 cases. There were 8,000 or more controls, depending on the analysis. Odds ratios for all sites increased with lower BMI, greater smoking, and greater drinking. In polytomous regression, odds ratios for BMI (P = 0.65), smoking (P = 0.52), and drinking (P = 0.73) were homogeneous for oral cavity and pharyngeal cancers. Odds ratios for BMI and drinking were greater for oral cavity/pharyngeal cancer (P < 0.01), while smoking odds ratios were greater for laryngeal cancer (P < 0.01). Lower BMI enhanced smoking-and drinking-related odds ratios for oral cavity/pharyngeal cancer (P < 0.01), while BMI did not modify smoking and drinking odds ratios for laryngeal cancer.

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KW - Body mass index

KW - Laryngeal neoplasms

KW - Models, statistical

KW - Mouth neoplasms

KW - Odds ratio

KW - Pharyngeal neoplasms

KW - Smoking

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Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: Modeling odds ratios in pooled case-control data

Abstract

Keywords

ASJC Scopus subject areas

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