TY - JOUR
T1 - Body surface area and body weight predict total liver volume in western adults
AU - Vauthey, Jean Nicolas
AU - Abdalla, Eddie K.
AU - Doherty, Dorota A.
AU - Gertsch, Philippe
AU - Fenstermacher, Marc J.
AU - Loyer, Evelyne M.
AU - Lerut, Jan
AU - Materne, Roland
AU - Wang, Xuemei
AU - Encarnacion, Arthur
AU - Herron, Delise
AU - Mathey, Christian
AU - Ferrari, Giovanni
AU - Charnsangavej, Chuslip
AU - Do, Kim Anh
AU - Denys, Alban
PY - 2002
Y1 - 2002
N2 - Computed tomography (CT) is used increasingly to measure liver volume in patients undergoing evaluation for transplantation or resection. This study is designed to determine a formula predicting total liver volume (TLV) based on body surface area (BSA) or body weight in Western adults. TLV was measured in 292 patients from four Western centers. Liver volumes were calculated from helical computed tomographic scans obtained for conditions unrelated to the hepatobiliary system. BSA was calculated based on height and weight. Each center used a different established method of three-dimensional volume reconstruction. Using regression analysis, measurements were compared, and formulas correlating BSA or body weight to TLV were established. A linear regression formula to estimate TLV based on BSA was obtained: TLV = -794.41 + 1,267.28 × BSA (square meters; r2 = 0.46; P <.0001). A formula based on patient weight also was derived: TLV = 191.80 + 18.51 × weight (kilograms; r2 = 0.49; P <.0001). The newly derived TLV formula based on BSA was compared with previously reported formulas. The application of a formula obtained from healthy Japanese individuals underestimated TLV. Two formulas derived from autopsy data for Western populations were similar to the newly derived BSA formula, with a slight overestimation of TLV. In conclusion, hepatic three-dimensional volume reconstruction based on helical CT predicts TLV based on BSA or body weight. The new formulas derived from this correlation should contribute to the estimation of TLV before liver transplantation or major hepatic resection.
AB - Computed tomography (CT) is used increasingly to measure liver volume in patients undergoing evaluation for transplantation or resection. This study is designed to determine a formula predicting total liver volume (TLV) based on body surface area (BSA) or body weight in Western adults. TLV was measured in 292 patients from four Western centers. Liver volumes were calculated from helical computed tomographic scans obtained for conditions unrelated to the hepatobiliary system. BSA was calculated based on height and weight. Each center used a different established method of three-dimensional volume reconstruction. Using regression analysis, measurements were compared, and formulas correlating BSA or body weight to TLV were established. A linear regression formula to estimate TLV based on BSA was obtained: TLV = -794.41 + 1,267.28 × BSA (square meters; r2 = 0.46; P <.0001). A formula based on patient weight also was derived: TLV = 191.80 + 18.51 × weight (kilograms; r2 = 0.49; P <.0001). The newly derived TLV formula based on BSA was compared with previously reported formulas. The application of a formula obtained from healthy Japanese individuals underestimated TLV. Two formulas derived from autopsy data for Western populations were similar to the newly derived BSA formula, with a slight overestimation of TLV. In conclusion, hepatic three-dimensional volume reconstruction based on helical CT predicts TLV based on BSA or body weight. The new formulas derived from this correlation should contribute to the estimation of TLV before liver transplantation or major hepatic resection.
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U2 - 10.1053/jlts.2002.31654
DO - 10.1053/jlts.2002.31654
M3 - Article
C2 - 11910568
AN - SCOPUS:18344386396
SN - 1527-6465
VL - 8
SP - 233
EP - 240
JO - Liver Transplantation
JF - Liver Transplantation
IS - 3
ER -